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PCBP1 Pre-design Chimera RNAi

  • Catalog # : H00005093-R01
  • Visit Frequency :
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  • Specification
  • Product Description:
  • Homo sapiens poly(rC) binding protein 1 (PCBP1), mRNA.
  • Reactivity:
  • Human
  • Supplied Product:
  • DEPC water
  • Target Refseq:
  • NM_006196
  • Storage Instruction:
  • Store at -20°C, do not exceed 4 - 5 freeze-thaw cycles to ensure product integrity.
  • Note:
  • Position of the Chimera RNAi.

  • Publication Reference
  • Applications
  • RNAi Knockdown
  • Application Image
  • RNAi Knockdown
  • Gene Information
  • Entrez GeneID:
  • 5093
  • Gene Name:
  • PCBP1
  • Gene Alias:
  • HNRPE1,HNRPX,hnRNP-E1,hnRNP-X
  • Gene Description:
  • poly(rC) binding protein 1
  • Gene Summary:
  • This intronless gene is thought to have been generated by retrotransposition of a fully processed PCBP-2 mRNA. This gene and PCBP-2 have paralogues (PCBP3 and PCBP4) which are thought to have arisen as a result of duplication events of entire genes. The protein encoded by this gene appears to be multifunctional. It along with PCBP-2 and hnRNPK corresponds to the major cellular poly(rC)-binding protein. It contains three K-homologous (KH) domains which may be involved in RNA binding. This encoded protein together with PCBP-2 also functions as translational coactivators of poliovirus RNA via a sequence-specific interaction with stem-loop IV of the IRES and promote poliovirus RNA replication by binding to its 5'-terminal cloverleaf structure. It has also been implicated in translational control of the 15-lipoxygenase mRNA, human Papillomavirus type 16 L2 mRNA, and hepatitis A virus RNA. The encoded protein is also suggested to play a part in formation of a sequence-specific alpha-globin mRNP complex which is associated with alpha-globin mRNA stability. [provided by RefSeq
  • Other Designations:
  • alpha-CP1,heterogeneous nuclear ribonucleoprotein E1,heterogenous nuclear ribonucleoprotein E1,heterogenous nuclear ribonucleoprotein X,nucleic acid binding protein sub 2.3
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