PARN 293T Cell Transient Overexpression Lysate(Denatured)
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More Files
- More Functions
SDS-PAGE Gel
PARN transfected lysate.
Western Blot
Lane 1: PARN transfected lysate ( 73.5 KDa)
Lane 2: Non-transfected lysate.
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Specification
Transfected Cell Line
293T
Plasmid
pCMV-PARN full-length
Host
Human
Theoretical MW (kDa)
73.5
Interspecies Antigen Sequence
Mouse (87); Rat (86)
Quality Control Testing
Transient overexpression cell lysate was tested with Anti-PARN antibody (H00005073-B01) by Western Blots.
SDS-PAGE Gel
PARN transfected lysate.
Western Blot
Lane 1: PARN transfected lysate ( 73.5 KDa)
Lane 2: Non-transfected lysate.Storage Buffer
1X Sample Buffer (50 mM Tris-HCl, 2% SDS, 10% glycerol, 300 mM 2-mercaptoethanol, 0.01% Bromophenol blue)
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot
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Gene Info — PARN
Entrez GeneID
5073GeneBank Accession#
NM_002582.1Protein Accession#
-Gene Name
PARN
Gene Alias
DAN
Gene Description
poly(A)-specific ribonuclease (deadenylation nuclease)
Omim ID
604212Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a 3'-exoribonuclease, with similarity to the RNase D family of 3'-exonucleases. It prefers poly(A) as the substrate, hence, efficiently degrades poly(A) tails of mRNAs. Exonucleolytic degradation of the poly(A) tail is often the first step in the decay of eukaryotic mRNAs. This protein is also involved in silencing of certain maternal mRNAs during oocyte maturation and early embryonic development, as well as in nonsense-mediated decay (NMD) of mRNAs that contain premature stop codons. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
Other Designations
deadenylating nuclease
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Interactome
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Pathway
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Disease
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