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PARN 293T Cell Transient Overexpression Lysate(Denatured)

  • Catalog # : H00005073-T01
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  • Specification
  • Transfected Cell Line:
  • 293T
  • Plasmid:
  • pCMV-PARN full-length
  • Host:
  • Human
  • Theoretical MW (kDa):
  • 73.5
  • Quality Control Testing:
  • Transient overexpression cell lysate was tested with Anti-PARN antibody (H00005073-B01) by Western Blots.
    SDS-PAGE Gel
    QC Testing of H00005073-T01
    PARN transfected lysate.
    Western Blot
    QC Testing of H00005073-T01
    Lane 1: PARN transfected lysate ( 73.5 KDa)
    Lane 2: Non-transfected lysate.
  • Storage Buffer:
  • 1X Sample Buffer (50 mM Tris-HCl, 2% SDS, 10% glycerol, 300 mM 2-mercaptoethanol, 0.01% Bromophenol blue)
  • Storage Instruction:
  • Store at -80°C. Aliquot to avoid repeated freezing and thawing.
  • Applications
  • Western Blot
  • Application Image
  • Western Blot
  • Gene Information
  • Entrez GeneID:
  • 5073
  • Protein Accession#:
  • -
  • Gene Name:
  • PARN
  • Gene Alias:
  • DAN
  • Gene Description:
  • poly(A)-specific ribonuclease (deadenylation nuclease)
  • Gene Summary:
  • The protein encoded by this gene is a 3'-exoribonuclease, with similarity to the RNase D family of 3'-exonucleases. It prefers poly(A) as the substrate, hence, efficiently degrades poly(A) tails of mRNAs. Exonucleolytic degradation of the poly(A) tail is often the first step in the decay of eukaryotic mRNAs. This protein is also involved in silencing of certain maternal mRNAs during oocyte maturation and early embryonic development, as well as in nonsense-mediated decay (NMD) of mRNAs that contain premature stop codons. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
  • Other Designations:
  • deadenylating nuclease
  • Gene Pathway
  • Related Disease
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