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Last updated: 2017/5/21

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PARN Pre-design Chimera RNAi

  • Catalog # : H00005073-R01
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  • Specification
  • Product Description:
  • Homo sapiens poly(A)-specific ribonuclease (deadenylation nuclease) (PARN), mRNA.
  • Reactivity:
  • Human
  • Supplied Product:
  • DEPC water
  • Target Refseq:
  • NM_002582
  • Storage Instruction:
  • Store at -20°C, do not exceed 4 - 5 freeze-thaw cycles to ensure product integrity.
  • Note:
  • Position of the Chimera RNAi.

  • Publication Reference
  • Applications
  • RNAi Knockdown
  • Application Image
  • RNAi Knockdown
  • Gene Information
  • Entrez GeneID:
  • 5073
  • Gene Name:
  • PARN
  • Gene Alias:
  • DAN
  • Gene Description:
  • poly(A)-specific ribonuclease (deadenylation nuclease)
  • Gene Summary:
  • The protein encoded by this gene is a 3'-exoribonuclease, with similarity to the RNase D family of 3'-exonucleases. It prefers poly(A) as the substrate, hence, efficiently degrades poly(A) tails of mRNAs. Exonucleolytic degradation of the poly(A) tail is often the first step in the decay of eukaryotic mRNAs. This protein is also involved in silencing of certain maternal mRNAs during oocyte maturation and early embryonic development, as well as in nonsense-mediated decay (NMD) of mRNAs that contain premature stop codons. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
  • Other Designations:
  • deadenylating nuclease
  • Gene Pathway
  • Related Disease
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