PARN polyclonal antibody (A01)
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More Files
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Western Blot (Tissue lysate)
PARN polyclonal antibody (A01), Lot # 051019JC01. Western Blot analysis of PARN expression in human ovarian cancer.
Western Blot detection against Immunogen (37 KDa) .
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Specification
Product Description
Mouse polyclonal antibody raised against a partial recombinant PARN.
Immunogen
PARN (NP_002573, 501 a.a. ~ 599 a.a) partial recombinant protein with GST tag.
Sequence
AESYRIQTYAEYMGRKQEEKQIKRKWTEDSWKEADSKRLNPQCIPYTLQNHYYRNNSFTAPSTVGKRNLSPSQEEAGLEDGVSGEISDTELEQTDSCAE
Host
Mouse
Reactivity
Human
Interspecies Antigen Sequence
Mouse (63); Rat (63)
Quality Control Testing
Antibody Reactive Against Recombinant Protein.
Western Blot detection against Immunogen (37 KDa) .
Storage Buffer
50 % glycerol
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Tissue lysate)
PARN polyclonal antibody (A01), Lot # 051019JC01. Western Blot analysis of PARN expression in human ovarian cancer.Western Blot (Recombinant protein)
ELISA
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Gene Info — PARN
Entrez GeneID
5073GeneBank Accession#
NM_002582Protein Accession#
NP_002573Gene Name
PARN
Gene Alias
DAN
Gene Description
poly(A)-specific ribonuclease (deadenylation nuclease)
Omim ID
604212Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a 3'-exoribonuclease, with similarity to the RNase D family of 3'-exonucleases. It prefers poly(A) as the substrate, hence, efficiently degrades poly(A) tails of mRNAs. Exonucleolytic degradation of the poly(A) tail is often the first step in the decay of eukaryotic mRNAs. This protein is also involved in silencing of certain maternal mRNAs during oocyte maturation and early embryonic development, as well as in nonsense-mediated decay (NMD) of mRNAs that contain premature stop codons. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
Other Designations
deadenylating nuclease
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Interactome
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Pathway
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Disease
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