PARK2 monoclonal antibody (M01), clone 1H4
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More Files
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Specification
Product Description
Mouse monoclonal antibody raised against a partial recombinant PARK2.
Immunogen
PARK2 (AAH22014, 288 a.a. ~ 387 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Sequence
PCVGTGDTVVLRGALGGFRRGVAGCPNSLIKELHHFRILGEEQYNRYQQYGAEECVLQMGGVLCPRPGCGAGLLPEPDQRKVTCEGGNGLGCGYGQRRTK
Host
Mouse
Reactivity
Human, Rat
Isotype
IgG3 Kappa
Quality Control Testing
Antibody Reactive Against Recombinant Protein.
Western Blot detection against Immunogen (36.74 KDa) .
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Cell lysate)
PARK2 monoclonal antibody (M01), clone 1H4. Western Blot analysis of PARK2 expression in PC-12.Western Blot (Recombinant protein)
Sandwich ELISA (Recombinant protein)
Detection limit for recombinant GST tagged PARK2 is 0.1 ng/ml as a capture antibody.ELISA
Immunofluorescence
Immunofluorescence of monoclonal antibody to PARK2 on HeLa cell. [antibody concentration 10 ug/ml] -
Gene Info — PARK2
Entrez GeneID
5071GeneBank Accession#
BC022014Protein Accession#
AAH22014Gene Name
PARK2
Gene Alias
AR-JP, LPRS2, PDJ, PRKN
Gene Description
Parkinson disease (autosomal recessive, juvenile) 2, parkin
Gene Ontology
HyperlinkGene Summary
The precise function of this gene is unknown; however, the encoded protein is a component of a multiprotein E3 ubiquitin ligase complex that mediates the targeting of substrate proteins for proteasomal degradation. Mutations in this gene are known to cause Parkinson disease and autosomal recessive juvenile Parkinson disease. Alternative splicing of this gene produces multiple transcript variants encoding distinct isoforms. Additional splice variants of this gene have been described but currently lack transcript support. [provided by RefSeq
Other Designations
E3 ubiquitin ligase|OTTHUMP00000017565|OTTHUMP00000017566|OTTHUMP00000017567|parkin|parkin 2
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Interactome
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Pathway
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Disease
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Publication Reference
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Regional and cellular localisation of Parkin Co-Regulated Gene in developing and adult mouse brain.
Brody KM, Taylor JM, Wilson GR, Delatycki MB, Lockhart PJ.
Brain Research 2008 Jan; 1201:177.
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Regional and cellular localisation of Parkin Co-Regulated Gene in developing and adult mouse brain.
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