PAPPA (Human) Recombinant Protein (Q01)
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More Files
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Specification
Product Description
Human PAPPA partial ORF ( NP_002572, 85 a.a. - 194 a.a.) recombinant protein with GST-tag at N-terminal.
Sequence
GATEEPSPPSRALYFSGRGEQLRLRADLELPRDAFTLQVWLRAEGGQRSPAVITGLYDKCSYISRDRGWVVGIHTISDQDNKDPRYFFSLKTDRARQVTTINAHRSYLPG
Host
Wheat Germ (in vitro)
Theoretical MW (kDa)
37.84
Interspecies Antigen Sequence
Mouse (91); Rat (88)
Preparation Method
Purification
Glutathione Sepharose 4 Fast Flow
Quality Control Testing
12.5% SDS-PAGE Stained with Coomassie Blue.
Storage Buffer
50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
Note
Best use within three months from the date of receipt of this protein.
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Applications
Enzyme-linked Immunoabsorbent Assay
Western Blot (Recombinant protein)
Antibody Production
Protein Array
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Gene Info — PAPPA
Entrez GeneID
5069GeneBank Accession#
NM_002581Protein Accession#
NP_002572Gene Name
PAPPA
Gene Alias
ASBABP2, DIPLA1, IGFBP-4ase, PAPA, PAPP-A, PAPPA1
Gene Description
pregnancy-associated plasma protein A, pappalysin 1
Omim ID
176385Gene Ontology
HyperlinkGene Summary
This gene encodes a secreted metalloproteinase which cleaves insulin-like growth factor binding proteins (IGFBPs). It is thought to be involved in local proliferative processes such as wound healing and bone remodeling. Low plasma level of this protein has been suggested as a biochemical marker for pregnancies with aneuploid fetuses. [provided by RefSeq
Other Designations
OTTHUMP00000022806|aspecific BCL2 ARE-binding protein 2|differentially placenta 1 expressed protein|insulin-like growth factor-dependent IGF binding protein-4 protease|pregnacy-associated plasma protein A|pregnancy-associated plasma protein A
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Interactome
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Disease
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