PAFAH1B1 (Human) Recombinant Protein (Q01)
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More Files
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Specification
Product Description
Human PAFAH1B1 partial ORF ( NP_000421, 1 a.a. - 110 a.a.) recombinant protein with GST-tag at N-terminal.
Sequence
MVLSQRQRDELNRAIADYLRSNGYEEAYSVFKKEAELDVNEELDKKYAGLLEKKWTSVIRLQKKVMELESKLNEAKEEFTSGGPLGQKRDPKEWIPRPPEKYALSGHRSP
Host
Wheat Germ (in vitro)
Theoretical MW (kDa)
37.84
Interspecies Antigen Sequence
Mouse (99); Rat (99)
Preparation Method
Purification
Glutathione Sepharose 4 Fast Flow
Quality Control Testing
12.5% SDS-PAGE Stained with Coomassie Blue.
Storage Buffer
50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
Note
Best use within three months from the date of receipt of this protein.
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Applications
Enzyme-linked Immunoabsorbent Assay
Western Blot (Recombinant protein)
Antibody Production
Protein Array
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Gene Info — PAFAH1B1
Entrez GeneID
5048GeneBank Accession#
NM_000430Protein Accession#
NP_000421Gene Name
PAFAH1B1
Gene Alias
LIS1, LIS2, MDCR, MDS, PAFAH
Gene Description
platelet-activating factor acetylhydrolase, isoform Ib, alpha subunit 45kDa
Gene Ontology
HyperlinkGene Summary
This locus was identified as encoding a gene that when mutated or lost caused the lissencephaly associated with Miller-Dieker lissencephaly syndrome. This gene encodes the non-catalytic alpha subunit of the intracellular Ib isoform of platelet-activating factor acteylhydrolase, a heterotrimeric enzyme that specifically catalyzes the removal of the acetyl group at the SN-2 position of platelet-activating factor (identified as 1-O-alkyl-2-acetyl-sn-glyceryl-3-phosphorylcholine). Two other isoforms of intracellular platelet-activating factor acetylhydrolase exist: one composed of multiple subunits, the other, a single subunit. In addition, a single-subunit isoform of this enzyme is found in serum. [provided by RefSeq
Other Designations
Platelet-activating factor acetylhydrolase, isoform 1B, alpha subunit|lissencephaly 1 protein|platelet-activating factor acetylhydrolase, isoform Ib, alpha subunit
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Interactome
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Pathway
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Disease
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