PAFAH1B1 rabbit monoclonal antibody
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Specification
Product Description
Rabbit monoclonal antibody raised against a human PAFAH1B1 peptide using ARM Technology.
Immunogen
A synthetic peptide of human PAFAH1B1 is used for rabbit immunization.
Customer or Abnova will decide on the preferred peptide sequence.Host
Rabbit
Library Construction
Non-fusion antibody library from rabbit spleen (ARM Technology).
Expression
Overexpression vector and transfection into 293H cell line.
Reactivity
Human
Purification
Protein A
Isotype
IgG
Quality Control Testing
Antibody reactive against human PAFAH1B1 peptide by ELISA and mammalian transfected lysate by Western Blot.
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
Deliverable
Up to three rabbit IgG clones of 100 ug each will be delivered to customer.
Note
1. Customer may provide cell or tissue lysate for antibody screening.
2. Rabbit monoclonal antibody generated by ARM technology is amenable to antibody engineering including F(ab)2, IgG, scFv and different Fc and non-Fc conjugates per customer request. -
Applications
Western Blot (Transfected lysate)
ELISA
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Gene Info — PAFAH1B1
Entrez GeneID
5048GeneBank Accession#
PAFAH1B1Gene Name
PAFAH1B1
Gene Alias
LIS1, LIS2, MDCR, MDS, PAFAH
Gene Description
platelet-activating factor acetylhydrolase, isoform Ib, alpha subunit 45kDa
Gene Ontology
HyperlinkGene Summary
This locus was identified as encoding a gene that when mutated or lost caused the lissencephaly associated with Miller-Dieker lissencephaly syndrome. This gene encodes the non-catalytic alpha subunit of the intracellular Ib isoform of platelet-activating factor acteylhydrolase, a heterotrimeric enzyme that specifically catalyzes the removal of the acetyl group at the SN-2 position of platelet-activating factor (identified as 1-O-alkyl-2-acetyl-sn-glyceryl-3-phosphorylcholine). Two other isoforms of intracellular platelet-activating factor acetylhydrolase exist: one composed of multiple subunits, the other, a single subunit. In addition, a single-subunit isoform of this enzyme is found in serum. [provided by RefSeq
Other Designations
Platelet-activating factor acetylhydrolase, isoform 1B, alpha subunit|lissencephaly 1 protein|platelet-activating factor acetylhydrolase, isoform Ib, alpha subunit
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Disease
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