P4HA1 purified MaxPab mouse polyclonal antibody (B01P)
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More Files
- More Functions
Western Blot (Transfected lysate)
Western Blot analysis of P4HA1 expression in transfected 293T cell line (H00005033-T01) by P4HA1 MaxPab polyclonal antibody.
Lane 1: P4HA1 transfected lysate(58.74 KDa).
Lane 2: Non-transfected lysate.
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Specification
Product Description
Mouse polyclonal antibody raised against a full-length human P4HA1 protein.
Immunogen
P4HA1 (NP_001017962.1, 1 a.a. ~ 534 a.a) full-length human protein.
Sequence
MIWYILIIGILLPQSLAHPGFFTSIGQMTDLIHTEKDLVTSLKDYIKAEEDKLEQIKKWAEKLDRLTSTATKDPEGFVGHPVNAFKLMKRLNTEWSELENLVLKDMSDGFISNLTIQRQYFPNDEDQVGAAKALLRLQDTYNLDTDTISKGNLPGVKHKSFLTAEDCFELGKVAYTEADYYHTELWMEQALRQLDEGEISTIDKVSVLDYLSYAVYQQGDLDKALLLTKKLLELDPEHQRANGNLKYFEYIMAKEKDVNKSASDDQSDQKTTPKKKGVAVDYLPERQKYEMLCRGEGIKMTPRRQKKLFCRYHDGNRNPKFILAPAKQEDEWDKPRIIRFHDIISDAEIEIVKDLAKPRLRRATISNPITGDLETVHYRISKSAWLSGYENPVVSRINMRIQDLTGLDVSTAEELQVANYGVGGQYEPHFDFARKDEPDAFKELGTGNRIATWLFYMSDVSAGGATVFPEVGASVWPKKGTAVFWYNLFASGEGDYSTRHAACPVLVGNKWVSNKWLHERGQEFRRPCTLSELE
Host
Mouse
Reactivity
Human
Quality Control Testing
Antibody reactive against mammalian transfected lysate.
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Transfected lysate)
Western Blot analysis of P4HA1 expression in transfected 293T cell line (H00005033-T01) by P4HA1 MaxPab polyclonal antibody.
Lane 1: P4HA1 transfected lysate(58.74 KDa).
Lane 2: Non-transfected lysate.
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Gene Info — P4HA1
Entrez GeneID
5033GeneBank Accession#
NM_001017962.1Protein Accession#
NP_001017962.1Gene Name
P4HA1
Gene Alias
P4HA
Gene Description
prolyl 4-hydroxylase, alpha polypeptide I
Omim ID
176710Gene Ontology
HyperlinkGene Summary
This gene encodes a component of prolyl 4-hydroxylase, a key enzyme in collagen synthesis composed of two identical alpha subunits and two beta subunits. The encoded protein is one of several different types of alpha subunits and provides the major part of the catalytic site of the active enzyme. In collagen and related proteins, prolyl 4-hydroxylase catalyzes the formation of 4-hydroxyproline that is essential to the proper three-dimensional folding of newly synthesized procollagen chains. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq
Other Designations
C-P4Halpha(I)|collagen prolyl 4-hydroxylase alpha(I)|procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha polypeptide I|prolyl 4-hydroxylase, alpha I subunit
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Interactome
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Pathway
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Disease
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Publication Reference
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BBF2H7-mediated Sec23A pathway is required for endoplasmic reticulum-to-Golgi trafficking in dermal fibroblasts to promote collagen synthesis.
IIshikura-Kinoshita S, Saeki H, Tsuji-Naito K.
The Journal of Investigative Dermatology 2012 Aug; 132(8):2010.
Application：WB, Human, Human dermal fibroblast (NHDF) cultures.
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Proteomic changes in articular cartilage of human endemic osteoarthritis in China.
Ma WJ, Guo X, Liu JT, Liu RY, Hu JW, Sun AG, Yu YX, Lammi MJ.
Proteomics 2011 May; 11:2881.
Application：WB-Ce, Human, Chondrocytes.
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BBF2H7-mediated Sec23A pathway is required for endoplasmic reticulum-to-Golgi trafficking in dermal fibroblasts to promote collagen synthesis.
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