OPHN1 rabbit monoclonal antibody
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Specification
Product Description
Rabbit monoclonal antibody raised against a human OPHN1 peptide using ARM Technology.
Immunogen
A synthetic peptide of human OPHN1 is used for rabbit immunization.
Customer or Abnova will decide on the preferred peptide sequence.Host
Rabbit
Library Construction
Non-fusion antibody library from rabbit spleen (ARM Technology).
Expression
Overexpression vector and transfection into 293H cell line.
Reactivity
Human
Purification
Protein A
Isotype
IgG
Quality Control Testing
Antibody reactive against human OPHN1 peptide by ELISA and mammalian transfected lysate by Western Blot.
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
Deliverable
Up to three rabbit IgG clones of 100 ug each will be delivered to customer.
Note
1. Customer may provide cell or tissue lysate for antibody screening.
2. Rabbit monoclonal antibody generated by ARM technology is amenable to antibody engineering including F(ab)2, IgG, scFv and different Fc and non-Fc conjugates per customer request. -
Applications
Western Blot (Transfected lysate)
ELISA
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Gene Info — OPHN1
Entrez GeneID
4983GeneBank Accession#
OPHN1Gene Name
OPHN1
Gene Alias
MRX60, OPN1
Gene Description
oligophrenin 1
Gene Ontology
HyperlinkGene Summary
This gene encodes a Rho-GTPase-activating protein that promotes GTP hydrolysis of Rho subfamily members. Rho proteins are important mediators of intracellular signal transduction, which affects cell migration and cell morphogenesis. Mutations in this gene are responsible for OPHN1-related X-linked mental retardation with cerebellar hypoplasia and distinctive facial dysmorhphism. [provided by RefSeq
Other Designations
OTTHUMP00000023451|mental retardation, X-linked 60|oligophrenin-1, Rho-GTPase activating protein
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Interactome
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Disease
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