Products

Western Blot (Cell lysate)

Western Blot (Transfected lysate)

Immunoprecipitation

Entrez GeneID

GeneBank Accession#

Protein Accession#

Gene Name

OGG1

Gene Alias

HMMH, HOGG1, MUTM, OGH1

Gene Description

8-oxoguanine DNA glycosylase

Omim ID

Gene Ontology

Gene Summary

This gene encodes the enzyme responsible for the excision of 8-oxoguanine, a mutagenic base byproduct which occurs as a result of exposure to reactive oxygen. The action of this enzyme includes lyase activity for chain cleavage. Alternative splicing of the C-terminal region of this gene classifies splice variants into two major groups, type 1 and type 2, depending on the last exon of the sequence. Type 1 alternative splice variants end with exon 7 and type 2 end with exon 8. All variants share the N-terminal region in common, which contains a mitochondrial targeting signal that is essential for mitochondrial localization. Many alternative splice variants for this gene have been described, but the full-length nature for every variant has not been determined. [provided by RefSeq

Other Designations

8-hydroxyguanine DNA glycosylase|OTTHUMP00000122619