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NUP98 293T Cell Transient Overexpression Lysate(Denatured)

  • Catalog # : H00004928-T03
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  • Specification
  • Transfected Cell Line:
  • 293T
  • Plasmid:
  • pCMV-NUP98 full-length
  • Host:
  • Human
  • Theoretical MW (kDa):
  • 66.77
  • Quality Control Testing:
  • Transient overexpression cell lysate was tested with Anti-VSNL1 antibody (H00004928-B01) by Western Blots.
    SDS-PAGE Gel
    QC Testing of H00004928-T03
    NUP98 transfected lysate.
    Western Blot
    QC Testing of H00004928-T03
    Lane 1: NUP98 transfected lysate ( 66.77 KDa)
    Lane 2: Non-transfected lysate.
  • Storage Buffer:
  • 1X Sample Buffer (50 mM Tris-HCl, 2% SDS, 10% glycerol, 300 mM 2-mercaptoethanol, 0.01% Bromophenol blue)
  • Storage Instruction:
  • Store at -80°C. Aliquot to avoid repeated freezing and thawing.
  • Applications
  • Western Blot
  • Application Image
  • Western Blot
  • Gene Information
  • Entrez GeneID:
  • 4928
  • Gene Name:
  • NUP98
  • Gene Alias:
  • ADIR2,NUP196,NUP96
  • Gene Description:
  • nucleoporin 98kDa
  • Gene Summary:
  • Signal-mediated nuclear import and export proceed through the nuclear pore complex (NPC), which is comprised of approximately 50 unique proteins collectively known as nucleoporins. The 98 kD nucleoporin is generated through a biogenesis pathway that involves synthesis and proteolytic cleavage of a 186 kD precursor protein. This cleavage results in the 98 kD nucleoporin as well as a 96 kD nucleoporin, both of which are localized to the nucleoplasmic side of the NPC. Rat studies show that the 98 kD nucleoporin functions as one of several docking site nucleoporins of transport substrates. The human gene has been shown to fuse to several genes following chromsome translocatons in acute myelogenous leukemia (AML) and T-cell acute lymphocytic leukemia (T-ALL). This gene is one of several genes located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. Alternative splicing of this gene results in several transcript variants; however, not all variants have been fully described. [provided by RefSeq
  • Other Designations:
  • GLFG-repeat containing nucleoporin,Nup98-Nup96,OTTHUMP00000013819,OTTHUMP00000013967,nucleoporin 98kD
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