NTRK3 monoclonal antibody (M04), clone 4D5
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Specification
Product Description
Mouse monoclonal antibody raised against a partial recombinant NTRK3.
Immunogen
NTRK3 (AAH13693, 41 a.a. ~ 160 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Sequence
TEINCRRPDDGNLFPLLEGQDSGNSNGNASINITDISRNITSIHIENWRSLHTLNAVDMELYTGLQKLTIKNSGLRSIQPRAFAKNPHLRYINLSSNRLTTLSWQLFQTLSLRELQLEQN
Host
Mouse
Reactivity
Human
Isotype
IgG2a Kappa
Quality Control Testing
Antibody Reactive Against Recombinant Protein.
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Sandwich ELISA (Recombinant protein)
Detection limit for recombinant GST tagged NTRK3 is approximately 3ng/ml as a capture antibody.ELISA
Immunofluorescence
Immunofluorescence of monoclonal antibody to NTRK3 on HeLa cell . [antibody concentration 10 ug/ml] -
Gene Info — NTRK3
Entrez GeneID
4916GeneBank Accession#
BC013693Protein Accession#
AAH13693Gene Name
NTRK3
Gene Alias
TRKC, gp145(trkC)
Gene Description
neurotrophic tyrosine kinase, receptor, type 3
Omim ID
191316Gene Ontology
HyperlinkGene Summary
This gene encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation and may play a role in the development of proprioceptive neurons that sense body position. Mutations in this gene have been associated with medulloblastomas, secretory breast carcinomas and other cancers. [provided by RefSeq
Other Designations
ETS related protein-neurotrophic receptor tyrosine kinase fusion protein|ETV6-NTRK3 fusion|NT-3 growth factor receptor|OTTHUMP00000192915|neurotrophin 3 receptor|tyrosine kinase receptor C
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Interactome
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Disease
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