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NPR2 rabbit monoclonal antibody

  • Catalog # : H00004882-K
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  • Specification
  • Product Description:
  • Rabbit monoclonal antibody raised against a human NPR2 peptide using ARM Technology.
  • Immunogen:
  • A synthetic peptide of human NPR2 is used for rabbit immunization.
    Customer or Abnova will decide on the preferred peptide sequence.
  • Host:
  • Rabbit
  • Reactivity:
  • Human
  • Purification:
  • Protein A
  • Isotype:
  • IgG
  • Quality Control Testing:
  • Antibody reactive against human NPR2 peptide by ELISA and mammalian transfected lysate by Western Blot.
  • Storage Buffer:
  • In 1x PBS, pH 7.4
  • Storage Instruction:
  • Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
  • Note:
  • 1. Customer may provide cell or tissue lysate for antibody screening.
    2. Rabbit monoclonal antibody generated by ARM technology is amenable to antibody engineering including F(ab)2, IgG, scFv and different Fc and non-Fc conjugates per customer request.
  • Library Construction:
  • Non-fusion antibody library from rabbit spleen (ARM Technology).
  • Expression:
  • Overexpression vector and transfection into 293H cell line.
  • Deliverable:
  • Up to three rabbit IgG clones of 1 mg each will be delivered to customer.
  • Applications
  • ELISA
  • Application Image
  • Western Blot (Transfected lysate)
  • ELISA
  • Gene Information
  • Entrez GeneID:
  • 4882
  • GeneBank Accession#:
  • NPR2
  • Gene Name:
  • NPR2
  • Gene Alias:
  • AMDM,ANPRB,GUC2B,GUCY2B,NPRB,NPRBi
  • Gene Description:
  • natriuretic peptide receptor B/guanylate cyclase B (atrionatriuretic peptide receptor B)
  • Gene Summary:
  • This gene encodes natriuretic peptide receptor B, one of two integral membrane receptors for natriuretic peptides. Both NPR1 and NPR2 contain five functional domains: an extracellular ligand-binding domain, a single membrane-spanning region, and intracellularly a protein kinase homology domain, a helical hinge region involved in oligomerization, and a carboxyl-terminal guanylyl cyclase catalytic domain. The protein is the primary receptor for C-type natriuretic peptide (CNP), which upon ligand binding exhibits greatly increased guanylyl cyclase activity. Mutations in this gene are the cause of acromesomelic dysplasia Maroteaux type. [provided by RefSeq
  • Other Designations:
  • OTTHUMP00000021345,OTTHUMP00000045390,atrial natriuretic peptide B-type receptor,guanylate cyclase B,natriuretic peptide receptor B
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