NPR2 rabbit monoclonal antibody
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Specification
Product Description
Rabbit monoclonal antibody raised against a human NPR2 peptide using ARM Technology.
Immunogen
A synthetic peptide of human NPR2 is used for rabbit immunization.
Customer or Abnova will decide on the preferred peptide sequence.Host
Rabbit
Library Construction
Non-fusion antibody library from rabbit spleen (ARM Technology).
Expression
Overexpression vector and transfection into 293H cell line.
Reactivity
Human
Purification
Protein A
Isotype
IgG
Quality Control Testing
Antibody reactive against human NPR2 peptide by ELISA and mammalian transfected lysate by Western Blot.
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
Deliverable
Up to three rabbit IgG clones of 100 ug each will be delivered to customer.
Note
1. Customer may provide cell or tissue lysate for antibody screening.
2. Rabbit monoclonal antibody generated by ARM technology is amenable to antibody engineering including F(ab)2, IgG, scFv and different Fc and non-Fc conjugates per customer request. -
Applications
Western Blot (Transfected lysate)
ELISA
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Gene Info — NPR2
Entrez GeneID
4882GeneBank Accession#
NPR2Gene Name
NPR2
Gene Alias
AMDM, ANPRB, GUC2B, GUCY2B, NPRB, NPRBi
Gene Description
natriuretic peptide receptor B/guanylate cyclase B (atrionatriuretic peptide receptor B)
Gene Ontology
HyperlinkGene Summary
This gene encodes natriuretic peptide receptor B, one of two integral membrane receptors for natriuretic peptides. Both NPR1 and NPR2 contain five functional domains: an extracellular ligand-binding domain, a single membrane-spanning region, and intracellularly a protein kinase homology domain, a helical hinge region involved in oligomerization, and a carboxyl-terminal guanylyl cyclase catalytic domain. The protein is the primary receptor for C-type natriuretic peptide (CNP), which upon ligand binding exhibits greatly increased guanylyl cyclase activity. Mutations in this gene are the cause of acromesomelic dysplasia Maroteaux type. [provided by RefSeq
Other Designations
OTTHUMP00000021345|OTTHUMP00000045390|atrial natriuretic peptide B-type receptor|guanylate cyclase B|natriuretic peptide receptor B
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