NPR1 (Human) Recombinant Protein (Q01)

Catalog # H00004881-Q01

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Size:25 ug
Price: USD $ 510.00
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  • Specifications

    Product Description

    Human NPR1 partial ORF ( AAH63304, 147 a.a. - 247 a.a.) recombinant protein with GST-tag at N-terminal.

    Sequence

    GVKDEYALTTRAGPSYAKLGDFVAALHRRLGWERQALMLYAYRPGDEEHCFFLVEGLFMRVRDRLNITVDHLEFAEDDLSHYTRLLRTMPRKGRVIYICSS

    Host

    Wheat Germ (in vitro)

    Theoretical MW (kDa)

    36.74

    Interspecies Antigen Sequence

    Mouse (77); Rat (75)

    Preparation Method

    in vitro wheat germ expression system

    Purification

    Glutathione Sepharose 4 Fast Flow

    Quality Control Testing

    12.5% SDS-PAGE Stained with Coomassie Blue.

    Storage Buffer

    50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.

    Storage Instruction

    Store at -80°C. Aliquot to avoid repeated freezing and thawing.

    Note

    Best use within three months from the date of receipt of this protein.

  • Applications

    Enzyme-linked Immunoabsorbent Assay

    Western Blot (Recombinant protein)

    Antibody Production

    Protein Array

  • Gene Info — NPR1

    Entrez GeneID

    4881

    GeneBank Accession#

    BC063304

    Protein Accession#

    AAH63304

    Gene Name

    NPR1

    Gene Alias

    ANPRA, ANPa, GUC2A, GUCY2A, NPRA

    Gene Description

    natriuretic peptide receptor A/guanylate cyclase A (atrionatriuretic peptide receptor A)

    Omim ID

    108960

    Gene Ontology

    Hyperlink

    Gene Summary

    Guanylyl cyclases, catalyzing the production of cGMP from GTP, are classified as soluble and membrane forms (Garbers and Lowe, 1994 [PubMed 7982997]). The membrane guanylyl cyclases, often termed guanylyl cyclases A through F, form a family of cell-surface receptors with a similar topographic structure: an extracellular ligand-binding domain, a single membrane-spanning domain, and an intracellular region that contains a protein kinase-like domain and a cyclase catalytic domain. GC-A and GC-B function as receptors for natriuretic peptides; they are also referred to as atrial natriuretic peptide receptor A (NPR1) and type B (NPR2; MIM 108961). Also see NPR3 (MIM 108962), which encodes a protein with only the ligand-binding transmembrane and 37-amino acid cytoplasmic domains. NPR1 is a membrane-bound guanylate cyclase that serves as the receptor for both atrial and brain natriuretic peptides (ANP (MIM 108780) and BNP (MIM 600295), respectively).[supplied by OMIM

    Other Designations

    OTTHUMP00000035155|atrionatriuretic peptide receptor A|guanylate cyclase A|natriuretic peptide A type receptor|natriuretic peptide receptor 1|natriuretic peptide receptor A

  • Interactomes
  • Pathways
  • Diseases
Contact Info
  • +1-909-264-1399
    +1-909-992-0619
    Toll Free : +1-877-853-6098
  • +1-909-992-3401
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