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Last updated: 2017/2/26

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NPC1 Pre-design Chimera RNAi

  • Catalog # : H00004864-R01
  • Visit Frequency :
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  • Specification
  • Product Description:
  • Homo sapiens Niemann-Pick disease, type C1 (NPC1), mRNA.
  • Reactivity:
  • Human
  • Supplied Product:
  • DEPC water
  • Target Refseq:
  • NM_000271
  • Storage Instruction:
  • Store at -20°C, do not exceed 4 - 5 freeze-thaw cycles to ensure product integrity.
  • Note:
  • Position of the Chimera RNAi.

  • Publication Reference
  • Applications
  • RNAi Knockdown
  • Application Image
  • RNAi Knockdown
  • Gene Information
  • Entrez GeneID:
  • 4864
  • Gene Name:
  • NPC1
  • Gene Alias:
  • NPC
  • Gene Description:
  • Niemann-Pick disease, type C1
  • Gene Summary:
  • This gene encodes a large protein that resides in the limiting membrane of endosomes and lysosomes and mediates intracellular cholesterol trafficking via binding of cholesterol to its N-terminal domain. It is predicted to have a cytoplasmic C-terminus, 13 transmembrane domains, and 3 large loops in the lumen of the endosome - the last loop being at the N-terminus. This protein transports low-density lipoproteins to late endosomal/lysosomal compartments where they are hydrolized and released as free cholesterol. Defects in this gene cause Niemann-Pick type C disease, a rare autosomal recessive neurodegenerative disorder characterized by over accumulation of cholesterol and glycosphingolipids in late endosomal/lysosomal compartments
  • Other Designations:
  • -
  • Gene Pathway
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