NFKBIB 293T Cell Transient Overexpression Lysate(Denatured)
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More Files
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Specification
Transfected Cell Line
293T
Plasmid
pCMV-NFKBIB full-length
Host
Human
Theoretical MW (kDa)
37.8
Quality Control Testing
Transient overexpression cell lysate was tested with Anti-NFKBIB antibody (H00004793-B01) by Western Blots.
SDS-PAGE Gel
NFKBIB transfected lysate.
Western Blot
Lane 1: NFKBIB transfected lysate ( 37.8 KDa)
Lane 2: Non-transfected lysate.Storage Buffer
1X Sample Buffer (50 mM Tris-HCl, 2% SDS, 10% glycerol, 300 mM 2-mercaptoethanol, 0.01% Bromophenol blue)
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot
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Gene Info — NFKBIB
Entrez GeneID
4793GeneBank Accession#
NM_002503.3Protein Accession#
-Gene Name
NFKBIB
Gene Alias
IKBB, TRIP9
Gene Description
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
Omim ID
604495Gene Ontology
HyperlinkGene Summary
NFKB1 (MIM 164011) or NFKB2 (MIM 164012) is bound to REL (MIM 164910), RELA (MIM 164014), or RELB (MIM 604758) to form the NFKB complex. The NFKB complex is inhibited by I-kappa-B proteins (NFKBIA, MIM 164008, or NFKBIB), which inactivate NF-kappa-B by trapping it in the cytoplasm. Phosphorylation of serine residues on the I-kappa-B proteins by kinases (IKBKA, MIM 600664 or IKBKB, MIM 603258) marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NF-kappa-B complex. Activated NFKB complex translocates into the nucleus and binds DNA at kappa-B-binding motifs such as 5-prime GGGRNNYYCC 3-prime or 5-prime HGGARNYYCC 3-prime (where H is A, C, or T; R is an A or G purine; and Y is a C or T pyrimidine).[supplied by OMIM
Other Designations
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Interactome
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