NEU1 (Human) Recombinant Protein (Q01)
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More Files
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Specification
Product Description
Human NEU1 partial ORF ( NP_000425, 334 a.a. - 415 a.a.) recombinant protein with GST-tag at N-terminal.
Sequence
NPAHPEFRVNLTLRWSFSNGTSWRKETVQLWPGPSGYSSLATLEGSMDGEEQAPQLYVLYEKGRNHYTESISVAKISVYGTL
Host
Wheat Germ (in vitro)
Theoretical MW (kDa)
34.76
Interspecies Antigen Sequence
Rat (82)
Preparation Method
Purification
Glutathione Sepharose 4 Fast Flow
Quality Control Testing
12.5% SDS-PAGE Stained with Coomassie Blue.
Storage Buffer
50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
Note
Best use within three months from the date of receipt of this protein.
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Applications
Enzyme-linked Immunoabsorbent Assay
Western Blot (Recombinant protein)
Antibody Production
Protein Array
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Gene Info — NEU1
Entrez GeneID
4758GeneBank Accession#
NM_000434Protein Accession#
NP_000425Gene Name
NEU1
Gene Alias
FLJ93471, NANH, NEU, SIAL1
Gene Description
sialidase 1 (lysosomal sialidase)
Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a lysosomal enzyme that cleaves terminal sialic acid residues from substrates such as glycoproteins and glycolipids. In the lysosome, this enzyme is part of a heterotrimeric complex together with beta-galactosidase and cathepsin A (the latter is also referred to as 'protective protein'). Mutations in this gene can lead to sialidosis, a lysosomal storage disease that can be type 1 (cherry red spot-myoclonus syndrome or normosomatic type), which is late-onset, or type 2 (the dysmorphic type), which occurs at an earlier age with increased severity. [provided by RefSeq
Other Designations
G9 sialidase|N-acetyl-alpha-neuraminidase 1|OTTHUMP00000029419|acetylneuraminyl hydrolase|exo-alpha-sialidase|lysosomal sialidase|neuraminidase
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Interactome
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Pathway
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Disease
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