NEU1 rabbit monoclonal antibody
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Specification
Product Description
Rabbit monoclonal antibody raised against a human NEU1 peptide using ARM Technology.
Immunogen
A synthetic peptide of human NEU1 is used for rabbit immunization.
Customer or Abnova will decide on the preferred peptide sequence.Host
Rabbit
Library Construction
Non-fusion antibody library from rabbit spleen (ARM Technology).
Expression
Overexpression vector and transfection into 293H cell line.
Reactivity
Human
Purification
Protein A
Isotype
IgG
Quality Control Testing
Antibody reactive against human NEU1 peptide by ELISA and mammalian transfected lysate by Western Blot.
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
Deliverable
Up to three rabbit IgG clones of 100 ug each will be delivered to customer.
Note
1. Customer may provide cell or tissue lysate for antibody screening.
2. Rabbit monoclonal antibody generated by ARM technology is amenable to antibody engineering including F(ab)2, IgG, scFv and different Fc and non-Fc conjugates per customer request. -
Applications
Western Blot (Transfected lysate)
ELISA
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Gene Info — NEU1
Entrez GeneID
4758GeneBank Accession#
NEU1Gene Name
NEU1
Gene Alias
FLJ93471, NANH, NEU, SIAL1
Gene Description
sialidase 1 (lysosomal sialidase)
Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a lysosomal enzyme that cleaves terminal sialic acid residues from substrates such as glycoproteins and glycolipids. In the lysosome, this enzyme is part of a heterotrimeric complex together with beta-galactosidase and cathepsin A (the latter is also referred to as 'protective protein'). Mutations in this gene can lead to sialidosis, a lysosomal storage disease that can be type 1 (cherry red spot-myoclonus syndrome or normosomatic type), which is late-onset, or type 2 (the dysmorphic type), which occurs at an earlier age with increased severity. [provided by RefSeq
Other Designations
G9 sialidase|N-acetyl-alpha-neuraminidase 1|OTTHUMP00000029419|acetylneuraminyl hydrolase|exo-alpha-sialidase|lysosomal sialidase|neuraminidase
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