Products

Enzyme-linked Immunoabsorbent Assay

Western Blot (Recombinant protein)

Antibody Production

Protein Array

Entrez GeneID

GeneBank Accession#

Protein Accession#

Gene Name

NDUFA1

Gene Alias

CI-MWFE, MWFE, ZNF183

Gene Description

NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 1, 7.5kDa

Omim ID

Gene Ontology

Gene Summary

The human NDUFA1 gene codes for an essential component of complex I of the respiratory chain, which transfers electrons from NADH to ubiquinone. It has been noted that the N-terminal hydrophobic domain has the potential to be folded into an alpha-helix spanning the inner mitochondrial membrane with a C-terminal hydrophilic domain interacting with globular subunits of complex I. The highly conserved two-domain structure suggests that this feature is critical for the protein function and might act as an anchor for the NADH:ubiquinone oxidoreductase complex at the inner mitochondrial membrane. However, the NDUFA1 peptide is one of about 31 components of the "hydrophobic protein" (HP) fraction of complex I which is involved in proton translocation. Thus the NDUFA1 peptide may also participate in that function. [provided by RefSeq

Other Designations

NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 1|NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 1 (7.5kD, MWFE)|NADH oxidoreductase subunit MWFE|NADH:ubiquinone oxidoreductase (complex 1)|OTTHUMP00000023930|type I dehydrogenase