NDUFA1 monoclonal antibody (M10), clone 2A4
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Specification
Product Description
Mouse monoclonal antibody raised against a full-length recombinant NDUFA1.
Immunogen
NDUFA1 (AAH00266, 1 a.a. ~ 70 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Sequence
MWFEILPGLSVMGVCLLIPGLATAYIHRFTNGGKEKRVAHFGYHWSLMERDRRISGVDRYYVSKGLENID
Host
Mouse
Reactivity
Human
Isotype
IgG2a Kappa
Quality Control Testing
Antibody Reactive Against Recombinant Protein.
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
ELISA
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Gene Info — NDUFA1
Entrez GeneID
4694GeneBank Accession#
BC000266Protein Accession#
AAH00266Gene Name
NDUFA1
Gene Alias
CI-MWFE, MWFE, ZNF183
Gene Description
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 1, 7.5kDa
Gene Ontology
HyperlinkGene Summary
The human NDUFA1 gene codes for an essential component of complex I of the respiratory chain, which transfers electrons from NADH to ubiquinone. It has been noted that the N-terminal hydrophobic domain has the potential to be folded into an alpha-helix spanning the inner mitochondrial membrane with a C-terminal hydrophilic domain interacting with globular subunits of complex I. The highly conserved two-domain structure suggests that this feature is critical for the protein function and might act as an anchor for the NADH:ubiquinone oxidoreductase complex at the inner mitochondrial membrane. However, the NDUFA1 peptide is one of about 31 components of the "hydrophobic protein" (HP) fraction of complex I which is involved in proton translocation. Thus the NDUFA1 peptide may also participate in that function. [provided by RefSeq
Other Designations
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 1|NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 1 (7.5kD, MWFE)|NADH oxidoreductase subunit MWFE|NADH:ubiquinone oxidoreductase (complex 1)|OTTHUMP00000023930|type I dehydrogenase
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Interactome
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Pathway
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