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Last updated: 2016/10/23
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NCF4 monoclonal antibody (M01), clone 3C10

  • Catalog # : H00004689-M01
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  • Specification
  • Product Description:
  • Mouse monoclonal antibody raised against a partial recombinant NCF4.
  • Immunogen:
  • NCF4 (AAH02798, 1 a.a. ~ 100 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
  • Sequence:
  • Host:
  • Mouse
  • Reactivity:
  • Human
  • Isotype:
  • IgG2a Kappa
  • Quality Control Testing:
  • Antibody Reactive Against Recombinant Protein.
  • Storage Buffer:
  • In 1x PBS, pH 7.4
  • Storage Instruction:
  • Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
  • Applications
  • Sandwich ELISA (Recombinant protein)
  • Sandwich ELISA (Recombinant protein)
  • Detection limit for recombinant GST tagged NCF4 is approximately 0.3ng/ml as a capture antibody.
  • PDF DownloadProtocol Download
  • Application Image
  • Sandwich ELISA (Recombinant protein)
  • Sandwich ELISA (Recombinant protein)
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  • Gene Information
  • Entrez GeneID:
  • 4689
  • Gene Name:
  • NCF4
  • Gene Alias:
  • Gene Description:
  • neutrophil cytosolic factor 4, 40kDa
  • Gene Summary:
  • The protein encoded by this gene is a cytosolic regulatory component of the superoxide-producing phagocyte NADPH-oxidase, a multicomponent enzyme system important for host defense. This protein is preferentially expressed in cells of myeloid lineage. It interacts primarily with neutrophil cytosolic factor 2 (NCF2/p67-phox) to form a complex with neutrophil cytosolic factor 1 (NCF1/p47-phox), which further interacts with the small G protein RAC1 and translocates to the membrane upon cell stimulation. This complex then activates flavocytochrome b, the membrane-integrated catalytic core of the enzyme system. The PX domain of this protein can bind phospholipid products of the PI(3) kinase, which suggests its role in PI(3) kinase-mediated signaling events. The phosphorylation of this protein was found to negatively regulate the enzyme activity. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq
  • Other Designations:
  • OTTHUMP00000028736,OTTHUMP00000043756,neutrophil NADPH oxidase factor 4,neutrophil cytosol factor 4,neutrophil cytosolic factor 4
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