NCF4 purified MaxPab rabbit polyclonal antibody (D01P)
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More Files
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Western Blot (Transfected lysate)
Western Blot analysis of NCF4 expression in transfected 293T cell line (H00004689-T02) by NCF4 MaxPab polyclonal antibody.
Lane 1: NCF4 transfected lysate(39.00 KDa).
Lane 2: Non-transfected lysate.
Immunofluorescence
Immunofluorescence of purified MaxPab antibody to NCF4 on HeLa cell. [antibody concentration 20 ug/ml]
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Specification
Product Description
Rabbit polyclonal antibody raised against a full-length human NCF4 protein.
Immunogen
NCF4 (NP_000622.2, 1 a.a. ~ 339 a.a) full-length human protein.
Sequence
MAVAQQLRAESDFEQLPDDVAISANIADIEEKRGFTSHFVFVIEVKTKGGSKYLIYRRYRQFHALQSKLEERFGPDSKSSALACTLPTLPAKVYVGVKQEIAEMRIPALNAYMKSLLSLPVWVLMDEDVRIFFYQSPYDSEQVPQALRRLRPRTRKVKSVSPQGNSVDRMAAPRAEALFDFTGNSKLELNFKAGDVIFLLSRINKDWLEGTVRGATGIFPLSFVKILKDFPEEDDPTNWLRCYYYEDTISTIKDIAVEEDLSSTPLLKDLLELTRREFQREDIALNYRDAEGDLVRLLSDEDVALMVRQARGLPSQKRLFPWKLHITQKDNYRVYNTMP
Host
Rabbit
Reactivity
Human
Quality Control Testing
Antibody reactive against mammalian transfected lysate.
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Transfected lysate)
Western Blot analysis of NCF4 expression in transfected 293T cell line (H00004689-T02) by NCF4 MaxPab polyclonal antibody.
Lane 1: NCF4 transfected lysate(39.00 KDa).
Lane 2: Non-transfected lysate.
Immunofluorescence
Immunofluorescence of purified MaxPab antibody to NCF4 on HeLa cell. [antibody concentration 20 ug/ml] -
Gene Info — NCF4
Entrez GeneID
4689GeneBank Accession#
NM_000631Protein Accession#
NP_000622.2Gene Name
NCF4
Gene Alias
MGC3810, NCF, P40PHOX, SH3PXD4
Gene Description
neutrophil cytosolic factor 4, 40kDa
Omim ID
601488Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a cytosolic regulatory component of the superoxide-producing phagocyte NADPH-oxidase, a multicomponent enzyme system important for host defense. This protein is preferentially expressed in cells of myeloid lineage. It interacts primarily with neutrophil cytosolic factor 2 (NCF2/p67-phox) to form a complex with neutrophil cytosolic factor 1 (NCF1/p47-phox), which further interacts with the small G protein RAC1 and translocates to the membrane upon cell stimulation. This complex then activates flavocytochrome b, the membrane-integrated catalytic core of the enzyme system. The PX domain of this protein can bind phospholipid products of the PI(3) kinase, which suggests its role in PI(3) kinase-mediated signaling events. The phosphorylation of this protein was found to negatively regulate the enzyme activity. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq
Other Designations
OTTHUMP00000028736|OTTHUMP00000043756|neutrophil NADPH oxidase factor 4|neutrophil cytosol factor 4|neutrophil cytosolic factor 4
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Interactome
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Pathway
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Disease
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