Products

Western Blot

Entrez GeneID

GeneBank Accession#

Protein Accession#

Gene Name

PPP1R12B

Gene Alias

MGC131980, MGC87886, MYPT2

Gene Description

protein phosphatase 1, regulatory (inhibitor) subunit 12B

Omim ID

Gene Ontology

Gene Summary

Myosin light chain phosphatase (MLCP) consists of three subunits- catalytic subunit, large subunit/myosin binding subunit (MBS) and small subunit (sm-M20). This gene is a multi-functional gene which encodes both MBS and sm-M20. MLCP regulates myosins and the dephosphorylation is enhanced by the presence of MBS. The sm-M20 is suggested to play a regulatory role in muscle contraction by binding to MBS. MBS is also encoded by another gene, myosin light chain phosphatase target subunit 1. sm-M20 shows higher binding affinity to this gene product than to myosin light chain phosphatase target subunit 2-MBS even though the two MBS proteins are highly similar. Although both MBSs increase the activity of MLCP, myosin light chain phosphatase target subunit 1-MBS is a more efficient activator. There are four alternatively spliced transcript variants described; two alter the MBS coding region and two alter the sm-M20 coding region of this gene. [provided by RefSeq

Other Designations

myosin phosphatase regulatory subunit|myosin phosphatase, target subunit 2