PPP1R12B purified MaxPab rabbit polyclonal antibody (D01P)
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More Files
- More Functions
Western Blot (Tissue lysate)
PPP1R12B MaxPab rabbit polyclonal antibody. Western Blot analysis of PPP1R12B expression in human kidney.
Western Blot (Transfected lysate)
Western Blot analysis of PPP1R12B expression in transfected 293T cell line (H00004660-T03) by PPP1R12B MaxPab polyclonal antibody.
Lane 1: PPP1R12B transfected lysate(43.30 KDa).
Lane 2: Non-transfected lysate.
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Specification
Product Description
Rabbit polyclonal antibody raised against a full-length human PPP1R12B protein.
Immunogen
PPP1R12B (ENSP00000349206, 1 a.a. ~ 386 a.a) full-length human protein.
Sequence
MAELEHLGGKRAESARMRRAEQLRRWRGSLTEQEPAERRGAGRQPLTRRGSPRVRFEDGAVFLAACSSGDTDEVRKLLARGADINTVNVDGLTALHQACIDENLDMVKFLVENRANVNQQDNEGWTPLHAAASCGYLNIAEYFINHGASVGIVNSEGEVPSDLAEEPAMKDLLLEQVKKQGVDLEQSRKEEEQQMLQDARQWLNSGKIEDVRQARSGATALHVAAAKGYSEVLRLLIQAGYELNVQDYDGWTPLHAAAHWGVKEACSILAEALCDMDIRNKLGQTPFDVADEGLVEHLELLQKKQNVLRSEKETRNKLIESDLNSKIQSGFFKNKEKMLYEEETPKSQEMEEENKESSSSSSEEEEGEDEASESETEKEAVLFWPF
Host
Rabbit
Reactivity
Human
Quality Control Testing
Antibody reactive against mammalian transfected lysate.
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Tissue lysate)
PPP1R12B MaxPab rabbit polyclonal antibody. Western Blot analysis of PPP1R12B expression in human kidney.Western Blot (Transfected lysate)
Western Blot analysis of PPP1R12B expression in transfected 293T cell line (H00004660-T03) by PPP1R12B MaxPab polyclonal antibody.
Lane 1: PPP1R12B transfected lysate(43.30 KDa).
Lane 2: Non-transfected lysate.
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Gene Info — PPP1R12B
Entrez GeneID
4660GeneBank Accession#
ENST00000356764Protein Accession#
ENSP00000349206Gene Name
PPP1R12B
Gene Alias
MGC131980, MGC87886, MYPT2
Gene Description
protein phosphatase 1, regulatory (inhibitor) subunit 12B
Omim ID
603768Gene Ontology
HyperlinkGene Summary
Myosin light chain phosphatase (MLCP) consists of three subunits- catalytic subunit, large subunit/myosin binding subunit (MBS) and small subunit (sm-M20). This gene is a multi-functional gene which encodes both MBS and sm-M20. MLCP regulates myosins and the dephosphorylation is enhanced by the presence of MBS. The sm-M20 is suggested to play a regulatory role in muscle contraction by binding to MBS. MBS is also encoded by another gene, myosin light chain phosphatase target subunit 1. sm-M20 shows higher binding affinity to this gene product than to myosin light chain phosphatase target subunit 2-MBS even though the two MBS proteins are highly similar. Although both MBSs increase the activity of MLCP, myosin light chain phosphatase target subunit 1-MBS is a more efficient activator. There are four alternatively spliced transcript variants described; two alter the MBS coding region and two alter the sm-M20 coding region of this gene. [provided by RefSeq
Other Designations
myosin phosphatase regulatory subunit|myosin phosphatase, target subunit 2
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Interactome
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Pathway
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Disease
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