GADD45B (Human) Recombinant Protein (P01)
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More Files
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Specification
Product Description
Human GADD45B full-length ORF ( ADR83481.1, 1 a.a. - 160 a.a.) recombinant protein with GST-tag at N-terminal.
Sequence
MTLEELVACDNAAQKMQTVTAAVEELLVAAQRQDRLTVGVYESAKLMNVDPDSVVLCLLAIDEEEEDDIALQIHFTLIQSFCCDNDINIVRVSGMQRLAQLLGEPAETQGTTEARDLHCLLVTNPHTDAWKSHGLVEVASYCEESRGNNQWVPYISLQER
Host
Wheat Germ (in vitro)
Theoretical MW (kDa)
17.6
Interspecies Antigen Sequence
Mouse (93); Rat (93)
Preparation Method
Purification
Glutathione Sepharose 4 Fast Flow
Storage Buffer
50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
Note
Best use within three months from the date of receipt of this protein.
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Applications
Enzyme-linked Immunoabsorbent Assay
Western Blot (Recombinant protein)
Antibody Production
Protein Array
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Gene Info — GADD45B
Entrez GeneID
4616GeneBank Accession#
HQ258730.1Protein Accession#
ADR83481.1Gene Name
GADD45B
Gene Alias
DKFZp566B133, GADD45BETA, MYD118
Gene Description
growth arrest and DNA-damage-inducible, beta
Omim ID
604948Gene Ontology
HyperlinkGene Summary
This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The genes in this group respond to environmental stresses by mediating activation of the p38/JNK pathway. This activation is mediated via their proteins binding and activating MTK1/MEKK4 kinase, which is an upstream activator of both p38 and JNK MAPKs. The function of these genes or their protein products is involved in the regulation of growth and apoptosis. These genes are regulated by different mechanisms, but they are often coordinately expressed and can function cooperatively in inhibiting cell growth. [provided by RefSeq
Other Designations
myeloid differentiation primary response
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Interactome
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Pathway
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Disease
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