MXI1 (Human) Recombinant Protein (Q01)
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More Files
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Specification
Product Description
Human MXI1 partial ORF ( NP_001008541.1, 73 a.a. - 182 a.a.) recombinant protein with GST-tag at N-terminal.
Sequence
LEEAERKSQHQLENLEREQRFLKWRLEQLQGPQEMERIRMDSIGSTISSDRSDSEREEIEVDVESTEFSHGEVDNISTTSISDIDDHSSLPSIGSDEGYSSASVKLSFTS
Host
Wheat Germ (in vitro)
Theoretical MW (kDa)
37.84
Interspecies Antigen Sequence
Mouse (93); Rat (98)
Preparation Method
Purification
Glutathione Sepharose 4 Fast Flow
Quality Control Testing
12.5% SDS-PAGE Stained with Coomassie Blue.
Storage Buffer
50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
Note
Best use within three months from the date of receipt of this protein.
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Applications
Enzyme-linked Immunoabsorbent Assay
Western Blot (Recombinant protein)
Antibody Production
Protein Array
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Gene Info — MXI1
Entrez GeneID
4601GeneBank Accession#
NM_001008541Protein Accession#
NP_001008541.1Gene Name
MXI1
Gene Alias
MAD2, MGC43220, MXD2, MXI, bHLHc11
Gene Description
MAX interactor 1
Gene Ontology
HyperlinkGene Summary
Expression of the c-myc gene, which produces an oncogenic transcription factor, is tightly regulated in normal cells but is frequently deregulated in human cancers. The protein encoded by this gene is a transcriptional repressor thought to negatively regulate MYC function, and is therefore a potential tumor suppressor. This protein inhibits the transcriptional activity of MYC by competing for MAX, another basic helix-loop-helix protein that binds to MYC and is required for its function. Defects in this gene are frequently found in patients with prostate tumors. Three alternatively spliced transcripts encoding different isoforms have been described. Additional alternatively spliced transcripts may exist but the products of these transcripts have not been verified experimentally. [provided by RefSeq
Other Designations
MAX dimerization protein 2|MAX interacting protein 1|MAX-interacting protein 1|Max-related transcription factor|OTTHUMP00000020467|OTTHUMP00000020468|OTTHUMP00000020469
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Interactome
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Disease
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