MUTYH (Human) Recombinant Protein (Q01)
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More Files
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Specification
Product Description
Human MUTYH partial ORF ( AAH03178, 436 a.a. - 535 a.a.) recombinant protein with GST-tag at N-terminal.
Sequence
KLTYQVYGLALEGQTPVTTVPPGARWLTQEEFHTAAVSTAMKKVFRVYQGQQPGTCMGSKRSQVSSPCSRKKPRMGQQVLDNFFRSHISTDAHSLNSAAQ
Host
Wheat Germ (in vitro)
Theoretical MW (kDa)
36.74
Interspecies Antigen Sequence
Mouse (70)
Preparation Method
Purification
Glutathione Sepharose 4 Fast Flow
Quality Control Testing
12.5% SDS-PAGE Stained with Coomassie Blue.
Storage Buffer
50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
Note
Best use within three months from the date of receipt of this protein.
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Applications
Enzyme-linked Immunoabsorbent Assay
Western Blot (Recombinant protein)
Antibody Production
Protein Array
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Gene Info — MUTYH
Entrez GeneID
4595GeneBank Accession#
BC003178Protein Accession#
AAH03178Gene Name
MUTYH
Gene Alias
MGC4416, MYH
Gene Description
mutY homolog (E. coli)
Gene Ontology
HyperlinkGene Summary
This gene encodes a DNA glycosylase involved in oxidative DNA damage repair. The enzyme excises adenine bases from the DNA backbone at sites where adenine is inappropriately paired with guanine, cytosine, or 8-oxo-7,8-dihydroguanine, a major oxidatively damaged DNA lesion. The protein is localized to the nucleus and mitochondria. Mutations in this gene result in heritable predisposition to colon and stomach cancer. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
Other Designations
A/G-specific adenine DNA glycosylase|OTTHUMP00000009096|OTTHUMP00000009098|OTTHUMP00000009101|OTTHUMP00000009102|mutY homolog
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Interactome
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Pathway
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Disease
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