MUTYH monoclonal antibody (M02), clone 1C8
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Specification
Product Description
Mouse monoclonal antibody raised against a partial recombinant MUTYH.
Immunogen
MUTYH (AAH03178, 436 a.a. ~ 535 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Sequence
KLTYQVYGLALEGQTPVTTVPPGARWLTQEEFHTAAVSTAMKKVFRVYQGQQPGTCMGSKRSQVSSPCSRKKPRMGQQVLDNFFRSHISTDAHSLNSAAQ
Host
Mouse
Reactivity
Human
Interspecies Antigen Sequence
Mouse (70)
Isotype
IgG1 Kappa
Quality Control Testing
Antibody Reactive Against Recombinant Protein.
Western Blot detection against Immunogen (36.74 KDa) .
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Recombinant protein)
ELISA
Immunofluorescence
Immunofluorescence of monoclonal antibody to MUTYH on HeLa cell . [antibody concentration 10 ug/ml] -
Gene Info — MUTYH
Entrez GeneID
4595GeneBank Accession#
BC003178Protein Accession#
AAH03178Gene Name
MUTYH
Gene Alias
MGC4416, MYH
Gene Description
mutY homolog (E. coli)
Gene Ontology
HyperlinkGene Summary
This gene encodes a DNA glycosylase involved in oxidative DNA damage repair. The enzyme excises adenine bases from the DNA backbone at sites where adenine is inappropriately paired with guanine, cytosine, or 8-oxo-7,8-dihydroguanine, a major oxidatively damaged DNA lesion. The protein is localized to the nucleus and mitochondria. Mutations in this gene result in heritable predisposition to colon and stomach cancer. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
Other Designations
A/G-specific adenine DNA glycosylase|OTTHUMP00000009096|OTTHUMP00000009098|OTTHUMP00000009101|OTTHUMP00000009102|mutY homolog
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Interactome
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Pathway
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Disease
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