MTNR1A (Human) Recombinant Protein (Q01)
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More Files
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Specification
Product Description
Human MTNR1A partial ORF ( NP_005949, 296 a.a. - 350 a.a.) recombinant protein with GST-tag at N-terminal.
Sequence
GLLNQNFRKEYRRIIVSLCTARVFFVDSSNDVADRVKWKPSPLMTNNNVVKVDSV
Host
Wheat Germ (in vitro)
Theoretical MW (kDa)
31.79
Interspecies Antigen Sequence
Mouse (75); Rat (80)
Preparation Method
Purification
Glutathione Sepharose 4 Fast Flow
Quality Control Testing
12.5% SDS-PAGE Stained with Coomassie Blue.
Storage Buffer
50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
Note
Best use within three months from the date of receipt of this protein.
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Applications
Enzyme-linked Immunoabsorbent Assay
Western Blot (Recombinant protein)
Antibody Production
Protein Array
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Gene Info — MTNR1A
Entrez GeneID
4543GeneBank Accession#
NM_005958Protein Accession#
NP_005949Gene Name
MTNR1A
Gene Alias
MEL-1A-R, MT1
Gene Description
melatonin receptor 1A
Omim ID
600665Gene Ontology
HyperlinkGene Summary
This gene encodes one of two high affinity forms of a receptor for melatonin, the primary hormone secreted by the pineal gland. This receptor is a G-protein coupled, 7-transmembrane receptor that is responsible for melatonin effects on mammalian circadian rhythm and reproductive alterations affected by day length. The receptor is an integral membrane protein that is readily detectable and localized to two specific regions of the brain. The hypothalamic suprachiasmatic nucleus appears to be involved in circadian rhythm while the hypophysial pars tuberalis may be responsible for the reproductive effects of melatonin. [provided by RefSeq
Other Designations
melatonin receptor type 1A
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Interactome
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Pathway
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Disease
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