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MSR1 Pre-design Chimera RNAi

  • Catalog # : H00004481-R01
  • Visit Frequency :
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  • Specification
  • Product Description:
  • Homo sapiens macrophage scavenger receptor 1 (MSR1), transcript variant SR-AII, mRNA.
  • Reactivity:
  • Human
  • Supplied Product:
  • DEPC water
  • Target Refseq:
  • NM_002445
  • Target Region:
  • 3' Untranslated Region (3'UTR)
  • Storage Instruction:
  • Store at -20°C, do not exceed 4 - 5 freeze-thaw cycles to ensure product integrity.
  • Note:
  • Position of the Chimera RNAi.
    The related RNAi products listed below were designed from different accesion number but sharing the same RNAi sequence.

  • Publication Reference
  • Applications
  • RNAi Knockdown
  • Application Image
  • RNAi Knockdown
  • Gene Information
  • Entrez GeneID:
  • 4481
  • Gene Name:
  • MSR1
  • Gene Alias:
  • CD204,SCARA1,SR-A,phSR1,phSR2
  • Gene Description:
  • macrophage scavenger receptor 1
  • Gene Summary:
  • This gene encodes the class A macrophage scavenger receptors, which include three different types (1, 2, 3) generated by alternative splicing of this gene. These receptors or isoforms are macrophage-specific trimeric integral membrane glycoproteins and have been implicated in many macrophage-associated physiological and pathological processes including atherosclerosis, Alzheimer's disease, and host defense. The isoforms type 1 and type 2 are functional receptors and are able to mediate the endocytosis of modified low density lipoproteins (LDLs). The isoform type 3 does not internalize modified LDL (acetyl-LDL) despite having the domain shown to mediate this function in the types 1 and 2 isoforms. It has an altered intracellular processing and is trapped within the endoplasmic reticulum, making it unable to perform endocytosis. The isoform type 3 can inhibit the function of isoforms type 1 and type 2 when co-expressed, indicating a dominant negative effect and suggesting a mechanism for regulation of scavenger receptor activity in macrophages. [provided by RefSeq
  • Other Designations:
  • OTTHUMP00000120049,OTTHUMP00000120050,macrophage acetylated LDL receptor I and II,macrophage scavenger receptor type III,scavenger receptor class A, member 1
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