MSR1 monoclonal antibody (M01), clone 2G8

Catalog # H00004481-M01

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Size:100 ug
Price: USD $ 335.00
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Sandwich ELISA (Recombinant protein)
Application

Sandwich ELISA (Recombinant protein)

Detection limit for recombinant GST tagged MSR1 is approximately 0.3ng/ml as a capture antibody.

QC Test

Western Blot detection against Immunogen (36.74 KDa) .

  • Specifications

    Product Description

    Mouse monoclonal antibody raised against a partial recombinant MSR1.

    Immunogen

    MSR1 (NP_619729, 121 a.a. ~ 220 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

    Sequence

    MEKRIQHILDMEANLMDTEHFQNFSMTTDQRFNDILLQLSTLFSSVQGHGNAIDEISKSLISLNTTLLDLQLNIENLNGKIQENTFKQQEEISKLKERVY

    Host

    Mouse

    Reactivity

    Human

    Interspecies Antigen Sequence

    Mouse (67); Rat (64)

    Isotype

    IgG3 Kappa

    Quality Control Testing

    Antibody Reactive Against Recombinant Protein.

    Western Blot detection against Immunogen (36.74 KDa) .

    Storage Buffer

    In 1x PBS, pH 7.4

    Storage Instruction

    Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.

  • Applications

    Western Blot (Recombinant protein)

    Sandwich ELISA (Recombinant protein)

    Detection limit for recombinant GST tagged MSR1 is approximately 0.3ng/ml as a capture antibody.

    ELISA

  • Gene Info — MSR1

    Entrez GeneID

    4481

    GeneBank Accession#

    NM_138715

    Protein Accession#

    NP_619729

    Gene Name

    MSR1

    Gene Alias

    CD204, SCARA1, SR-A, phSR1, phSR2

    Gene Description

    macrophage scavenger receptor 1

    Omim ID

    153622 176807

    Gene Ontology

    Hyperlink

    Gene Summary

    This gene encodes the class A macrophage scavenger receptors, which include three different types (1, 2, 3) generated by alternative splicing of this gene. These receptors or isoforms are macrophage-specific trimeric integral membrane glycoproteins and have been implicated in many macrophage-associated physiological and pathological processes including atherosclerosis, Alzheimer's disease, and host defense. The isoforms type 1 and type 2 are functional receptors and are able to mediate the endocytosis of modified low density lipoproteins (LDLs). The isoform type 3 does not internalize modified LDL (acetyl-LDL) despite having the domain shown to mediate this function in the types 1 and 2 isoforms. It has an altered intracellular processing and is trapped within the endoplasmic reticulum, making it unable to perform endocytosis. The isoform type 3 can inhibit the function of isoforms type 1 and type 2 when co-expressed, indicating a dominant negative effect and suggesting a mechanism for regulation of scavenger receptor activity in macrophages. [provided by RefSeq

    Other Designations

    OTTHUMP00000120049|OTTHUMP00000120050|macrophage acetylated LDL receptor I and II|macrophage scavenger receptor type III|scavenger receptor class A, member 1

  • Interactomes
  • Diseases
Contact Info
  • +1-909-264-1399
    +1-909-992-0619
    Toll Free : +1-877-853-6098
  • +1-909-992-3401
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