MSH2 monoclonal antibody (M02), clone 4B2
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More Files
- More Functions
Western Blot (Transfected lysate)
Western Blot analysis of MSH2 expression in transfected 293T cell line by MSH2 monoclonal antibody (M02), clone 4B2.
Lane 1: MSH2 transfected lysate (Predicted MW: 104.7 KDa).
Lane 2: Non-transfected lysate.
Sandwich ELISA (Recombinant protein)
Detection limit for recombinant GST tagged MSH2 is 1 ng/ml as a capture antibody.
In situ Proximity Ligation Assay (Cell)
Proximity Ligation Analysis of protein-protein interactions between MAX and MSH2. HeLa cells were stained with anti-MAX rabbit purified polyclonal 1:1200 and anti-MSH2 mouse monoclonal antibody 1:50. Each red dot represents the detection of protein-protein interaction complex, and nuclei were counterstained with DAPI (blue).
Western Blot detection against Immunogen (36.74 KDa) .
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Specification
Product Description
Mouse monoclonal antibody raised against a partial recombinant MSH2.
Immunogen
MSH2 (AAH21566, 835 a.a. ~ 934 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Sequence
NFPKHVIECAKQKALELEEFQYIGESQGYDIMEPAAKKCYLEREQGEKIIQEFLSKVKQMPFTEMSEENITIKLKQLKAEVIAKNNSFVNEIISRIKVTT
Host
Mouse
Reactivity
Human
Interspecies Antigen Sequence
Mouse (81); Rat (79)
Isotype
IgG2a Kappa
Quality Control Testing
Antibody Reactive Against Recombinant Protein.
Western Blot detection against Immunogen (36.74 KDa) .
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Transfected lysate)
Western Blot analysis of MSH2 expression in transfected 293T cell line by MSH2 monoclonal antibody (M02), clone 4B2.
Lane 1: MSH2 transfected lysate (Predicted MW: 104.7 KDa).
Lane 2: Non-transfected lysate.
Western Blot (Recombinant protein)
Sandwich ELISA (Recombinant protein)
Detection limit for recombinant GST tagged MSH2 is 1 ng/ml as a capture antibody.ELISA
In situ Proximity Ligation Assay (Cell)
Proximity Ligation Analysis of protein-protein interactions between MAX and MSH2. HeLa cells were stained with anti-MAX rabbit purified polyclonal 1:1200 and anti-MSH2 mouse monoclonal antibody 1:50. Each red dot represents the detection of protein-protein interaction complex, and nuclei were counterstained with DAPI (blue). -
Gene Info — MSH2
Entrez GeneID
4436GeneBank Accession#
BC021566Protein Accession#
AAH21566Gene Name
MSH2
Gene Alias
COCA1, FCC1, HNPCC, HNPCC1, LCFS2
Gene Description
mutS homolog 2, colon cancer, nonpolyposis type 1 (E. coli)
Gene Ontology
HyperlinkGene Summary
MSH2 was identified as a locus frequently mutated in hereditary nonpolyposis colon cancer (HNPCC). When cloned, it was discovered to be a human homolog of the E. coli mismatch repair gene mutS, consistent with the characteristic alterations in microsatellite sequences (RER+ phenotype) found in HNPCC. [provided by RefSeq
Other Designations
mutS homolog 2
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Interactome
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Pathway
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Disease
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