MRE11A monoclonal antibody (M01), clone 1D8-A6
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More Files
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Specification
Product Description
Mouse monoclonal antibody raised against a full length recombinant MRE11A.
Immunogen
MRE11A (AAH05241, 1 a.a. ~ 206 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Sequence
MSTADALDDENTFKILVATDIHLGFMEKDAVRGNDTFVTLDEILRLAQENEVDFILLGGDLFHENKPSRKTLHTCLELLRKYCMGDRPVQFEILSDQSVNFGFSKFPWVNYQDGNLNISIPVFSIHGNHDDPTGADALCALDILSCAGFVNHFGRSMSVEKIDISPVLLQKGRTKIALYGLGSIPDERLYRMFVNKKVTMLRPKED
Host
Mouse
Reactivity
Human
Interspecies Antigen Sequence
Mouse (94); Rat (94)
Isotype
IgG2a kappa
Quality Control Testing
Antibody Reactive Against Recombinant Protein.
Western Blot detection against Immunogen (48.4 KDa) .
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Cell lysate)
MRE11A monoclonal antibody (M01), clone 1D8-A6 Western Blot analysis of MRE11A expression in HL-60 ( Cat # L014V1 ).Western Blot (Recombinant protein)
ELISA
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Gene Info — MRE11A
Entrez GeneID
4361GeneBank Accession#
BC005241Protein Accession#
AAH05241Gene Name
MRE11A
Gene Alias
ATLD, HNGS1, MRE11, MRE11B
Gene Description
MRE11 meiotic recombination 11 homolog A (S. cerevisiae)
Gene Ontology
HyperlinkGene Summary
This gene encodes a nuclear protein involved in homologous recombination, telomere length maintenance, and DNA double-strand break repair. By itself, the protein has 3' to 5' exonuclease activity and endonuclease activity. The protein forms a complex with the RAD50 homolog; this complex is required for nonhomologous joining of DNA ends and possesses increased single-stranded DNA endonuclease and 3' to 5' exonuclease activities. In conjunction with a DNA ligase, this protein promotes the joining of noncomplementary ends in vitro using short homologies near the ends of the DNA fragments. This gene has a pseudogene on chromosome 3. Alternative splicing of this gene results in two transcript variants encoding different isoforms. [provided by RefSeq
Other Designations
AT-like disease|DNA recombination and repair protein|double-strand break repair protein MRE11A|endo/exonuclease Mre11|meiotic recombination 11 homolog A
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Interactome
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Pathway
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Disease
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