MPL (Human) IP-WB Antibody Pair

Catalog # H00004352-PW1

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Size:1 Set
Price: USD $ 607.00
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Immunoprecipitation of MPL transfected lysate using rabbit polyclonal anti-MPL and Protein A Magnetic Bead (U0007), and immunoblotted with mouse purified polyclonal anti-MPL.

  • Specifications

    Product Description

    This IP-WB antibody pair set comes with one antibody for immunoprecipitation and another to detect the precipitated protein in western blot.

    Reactivity

    Human

    Interspecies Antigen Sequence

    Mouse (81%); Rat (79%)

    Quality Control Testing

    Immunoprecipitation-Western Blot (IP-WB)

    Immunoprecipitation of MPL transfected lysate using rabbit polyclonal anti-MPL and Protein A Magnetic Bead (U0007), and immunoblotted with mouse purified polyclonal anti-MPL.

    Supplied Product

    Antibody pair set content:
    1. Antibody pair for IP: rabbit polyclonal anti-MPL (300 ul)
    2. Antibody pair for WB: mouse purified polyclonal anti-MPL (50 ug)

    Storage Instruction

    Store reagents of the antibody pair set at -20°C or lower. Please aliquot to avoid repeated freeze thaw cycle. Reagents should be returned to -20°C storage immediately after use.

  • Applications

    Immunoprecipitation-Western Blot

  • Gene Info — MPL

    Entrez GeneID

    4352

    Gene Name

    MPL

    Gene Alias

    C-MPL, CD110, MPLV, TPOR

    Gene Description

    myeloproliferative leukemia virus oncogene

    Omim ID

    159530 187950 604498

    Gene Ontology

    Hyperlink

    Gene Summary

    In 1990 an oncogene, v-mpl, was identified from the murine myeloproliferative leukemia virus that was capable of immortalizing bone marrow hematopoietic cells from different lineages. In 1992 the human homologue, named, c-mpl, was cloned. Sequence data revealed that c-mpl encoded a protein that was homologous with members of the hematopoietic receptor superfamily. Presence of anti-sense oligodeoxynucleotides of c-mpl inhibited megakaryocyte colony formation. The ligand for c-mpl, thrombopoietin, was cloned in 1994. Thrombopoietin was shown to be the major regulator of megakaryocytopoiesis and platelet formation. The protein encoded by the c-mpl gene, CD110, is a 635 amino acid transmembrane domain, with two extracellular cytokine receptor domains and two intracellular cytokine receptor box motifs . TPO-R deficient mice were severely thrombocytopenic, emphasizing the important role of CD110 and thrombopoietin in megakaryocyte and platelet formation. Upon binding of thrombopoietin CD110 is dimerized and the JAK family of non-receptor tyrosine kinases, as well as the STAT family, the MAPK family, the adaptor protein Shc and the receptors themselves become tyrosine phosphorylated. [provided by RefSeq

    Other Designations

    OTTHUMP00000008582|thrombopoietin receptor

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Contact Info
  • +1-909-264-1399
    +1-909-992-0619
    Toll Free : +1-877-853-6098
  • +1-909-992-3401
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