MMP12 293T Cell Transient Overexpression Lysate(Denatured)
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Specification
Transfected Cell Line
293T
Plasmid
pCMV-MMP12 full-length
Host
Human
Theoretical MW (kDa)
54
Quality Control Testing
Transient overexpression cell lysate was tested with Anti-MMP12 antibody (H00004321-B01) by Western Blots.
SDS-PAGE Gel
MMP12 transfected lysate.
Western Blot
Lane 1: MMP12 transfected lysate ( 54.00 KDa)
Lane 2: Non-transfected lysate.Storage Buffer
1X Sample Buffer (50 mM Tris-HCl, 2% SDS, 10% glycerol, 300 mM 2-mercaptoethanol, 0.01% Bromophenol blue)
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot
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Gene Info — MMP12
Entrez GeneID
4321GeneBank Accession#
NM_002426Protein Accession#
NP_002417.2Gene Name
MMP12
Gene Alias
HME, MGC138506, MME
Gene Description
matrix metallopeptidase 12 (macrophage elastase)
Omim ID
601046Gene Ontology
HyperlinkGene Summary
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. It is thought that the protein encoded by this gene is cleaved at both ends to yield the active enzyme, but this processing has not been fully described. The enzyme degrades soluble and insoluble elastin. It may play a role in aneurysm formation and studies in mice suggest a role in the development of emphysema. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. [provided by RefSeq
Other Designations
macrophage elastase|macrophage metalloelastase|matrix metalloproteinase 12|matrix metalloproteinase 12 (macrophage elastase)
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Interactome
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