MMP8 293T Cell Transient Overexpression Lysate(Denatured)
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More Files
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Specification
Transfected Cell Line
293T
Plasmid
pCMV-MMP8 full-length
Host
Human
Theoretical MW (kDa)
53.4
Interspecies Antigen Sequence
Mouse (74); Rat (72)
Quality Control Testing
Transient overexpression cell lysate was tested with Anti-MMP8 antibody (H00004317-B01) by Western Blots.
SDS-PAGE Gel
MMP8 transfected lysate
Western Blot
Lane 1: MMP8 transfected lysate ( 53.4 KDa).
Lane 2: Non-transfected lysate.Storage Buffer
1X Sample Buffer (50 mM Tris-HCl, 2% SDS, 10% glycerol, 300 mM 2-mercaptoethanol, 0.01% Bromophenol blue)
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot
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Gene Info — MMP8
Entrez GeneID
4317GeneBank Accession#
NM_002424Protein Accession#
NP_002415Gene Name
MMP8
Gene Alias
CLG1, HNC, PMNL-CL
Gene Description
matrix metallopeptidase 8 (neutrophil collagenase)
Omim ID
120355Gene Ontology
HyperlinkGene Summary
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the enzyme encoded by this gene is stored in secondary granules within neutrophils and is activated by autolytic cleavage. Its function is degradation of type I, II and III collagens. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. [provided by RefSeq
Other Designations
PMNL collagenase|matrix metalloproteinase 8|matrix metalloproteinase 8 (neutrophil collagenase)|neutrophil collagenase
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Interactome
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