MMP8 (Human) IP-WB Antibody Pair
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Specification
Product Description
This IP-WB antibody pair set comes with one antibody for immunoprecipitation and another to detect the precipitated protein in western blot.
Reactivity
Human
Interspecies Antigen Sequence
Mouse (73%); Rat (72%)
Quality Control Testing
Immunoprecipitation-Western Blot (IP-WB)
Immunoprecipitation of MMP8 transfected lysate using rabbit polyclonal anti-MMP8 and Protein A Magnetic Bead (U0007), and immunoblotted with mouse purified polyclonal anti-MMP8.
Supplied Product
Antibody pair set content:
1. Antibody pair for IP: rabbit polyclonal anti-MMP8 (300 ul)
2. Antibody pair for WB: mouse purified polyclonal anti-MMP8 (50 ug)
Storage Instruction
Store reagents of the antibody pair set at -20°C or lower. Please aliquot to avoid repeated freeze thaw cycle. Reagents should be returned to -20°C storage immediately after use.
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Applications
Immunoprecipitation-Western Blot
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Gene Info — MMP8
Entrez GeneID
4317Gene Name
MMP8
Gene Alias
CLG1, HNC, PMNL-CL
Gene Description
matrix metallopeptidase 8 (neutrophil collagenase)
Omim ID
120355Gene Ontology
HyperlinkGene Summary
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the enzyme encoded by this gene is stored in secondary granules within neutrophils and is activated by autolytic cleavage. Its function is degradation of type I, II and III collagens. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. [provided by RefSeq
Other Designations
PMNL collagenase|matrix metalloproteinase 8|matrix metalloproteinase 8 (neutrophil collagenase)|neutrophil collagenase
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Interactome
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Disease
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