MLH1 (Human) Recombinant Protein (Q01)
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More Files
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Specification
Product Description
Human MLH1 partial ORF ( NP_000240, 647 a.a. - 756 a.a.) recombinant protein with GST-tag at N-terminal.
Sequence
VPPLEGLPIFILRLATEVNWDEEKECFESLSKECAMFYSIRKQYISEESTLSGQQSEVPGSIPNSWKWTVEHIVYKALRSHILPPKHFTEDGNILQLANLPDLYKVFERC
Host
Wheat Germ (in vitro)
Theoretical MW (kDa)
37.84
Interspecies Antigen Sequence
Mouse (90)
Preparation Method
Purification
Glutathione Sepharose 4 Fast Flow
Quality Control Testing
12.5% SDS-PAGE Stained with Coomassie Blue.
Storage Buffer
50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
Note
Best use within three months from the date of receipt of this protein.
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Applications
Enzyme-linked Immunoabsorbent Assay
Western Blot (Recombinant protein)
Antibody Production
Protein Array
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Gene Info — MLH1
Entrez GeneID
4292GeneBank Accession#
NM_000249Protein Accession#
NP_000240Gene Name
MLH1
Gene Alias
COCA2, FCC2, HNPCC, HNPCC2, MGC5172, hMLH1
Gene Description
mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli)
Gene Ontology
HyperlinkGene Summary
This gene was identified as a locus frequently mutated in hereditary nonpolyposis colon cancer (HNPCC). It is a human homolog of the E. coli DNA mismatch repair gene mutL, consistent with the characteristic alterations in microsatellite sequences (RER+ phenotype) found in HNPCC. Alternatively spliced transcript variants encoding different isoforms have been described, but their full-length natures have not been determined. [provided by RefSeq
Other Designations
DNA mismatch repair protein Mlh1|MutL protein homolog 1
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Interactome
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