MLH1 rabbit monoclonal antibody
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Specification
Product Description
Rabbit monoclonal antibody raised against a human MLH1 peptide using ARM Technology.
Immunogen
A synthetic peptide of human MLH1 is used for rabbit immunization.
Customer or Abnova will decide on the preferred peptide sequence.Host
Rabbit
Library Construction
Non-fusion antibody library from rabbit spleen (ARM Technology).
Expression
Overexpression vector and transfection into 293H cell line.
Reactivity
Human
Purification
Protein A
Isotype
IgG
Quality Control Testing
Antibody reactive against human MLH1 peptide by ELISA and mammalian transfected lysate by Western Blot.
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
Deliverable
Up to three rabbit IgG clones of 100 ug each will be delivered to customer.
Note
1. Customer may provide cell or tissue lysate for antibody screening.
2. Rabbit monoclonal antibody generated by ARM technology is amenable to antibody engineering including F(ab)2, IgG, scFv and different Fc and non-Fc conjugates per customer request. -
Applications
Western Blot (Transfected lysate)
ELISA
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Gene Info — MLH1
Entrez GeneID
4292GeneBank Accession#
MLH1Gene Name
MLH1
Gene Alias
COCA2, FCC2, HNPCC, HNPCC2, MGC5172, hMLH1
Gene Description
mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli)
Gene Ontology
HyperlinkGene Summary
This gene was identified as a locus frequently mutated in hereditary nonpolyposis colon cancer (HNPCC). It is a human homolog of the E. coli DNA mismatch repair gene mutL, consistent with the characteristic alterations in microsatellite sequences (RER+ phenotype) found in HNPCC. Alternatively spliced transcript variants encoding different isoforms have been described, but their full-length natures have not been determined. [provided by RefSeq
Other Designations
DNA mismatch repair protein Mlh1|MutL protein homolog 1
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