MFNG (Human) Recombinant Protein (Q01)
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More Files
- More Functions
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Specification
Product Description
Human MFNG partial ORF ( NP_002396, 214 a.a. - 291 a.a.) recombinant protein with GST-tag at N-terminal.
Sequence
WASGSRFMDTSALIRLPDDCTMGYIIECKLGGRLQPSPLFHSHLETLQLLRTAQLPEQVTLSYGVFEGKLNVIKLQGP
Host
Wheat Germ (in vitro)
Theoretical MW (kDa)
34.32
Preparation Method
Purification
Glutathione Sepharose 4 Fast Flow
Quality Control Testing
12.5% SDS-PAGE Stained with Coomassie Blue.
Storage Buffer
50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
Note
Best use within three months from the date of receipt of this protein.
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Applications
Enzyme-linked Immunoabsorbent Assay
Western Blot (Recombinant protein)
Antibody Production
Protein Array
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Gene Info — MFNG
Entrez GeneID
4242GeneBank Accession#
NM_002405Protein Accession#
NP_002396Gene Name
MFNG
Gene Alias
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Gene Description
MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
Omim ID
602577Gene Ontology
HyperlinkGene Summary
This gene is a member of the fringe gene family which also includes Radical and Lunatic fringe. They all encode evolutionarily conserved secreted proteins that act in the Notch receptor pathway to demarcate boundaries during embryonic development. While their genomic structure is distinct from other glycosyltransferases, fringe proteins have a fucose-specific beta1,3 N-acetylglucosaminyltransferase activity that leads to elongation of O-linked fucose residues on Notch, which alters Notch signaling. [provided by RefSeq
Other Designations
O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase|OTTHUMP00000043697|OTTHUMP00000043698|OTTHUMP00000043700|beta-1,3-N-acetylglucosaminyltransferase manic fringe|manic fringe homolog
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Interactome
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Pathway
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Disease
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