MAP3K4 monoclonal antibody (M11A), clone X1
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More Files
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Specification
Product Description
Mouse monoclonal antibody raised against a partial recombinant MAP3K4.
Immunogen
MAP3K4 (NP_005913, 1201 a.a. ~ 1300 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Sequence
AASRPSPSGGDSVLPKSISSAHDTRGSSVPENDRLASIAAELQFRSLSRHSSPTEERDEPAYPRGDSSGSTRRSWELRTLISQSKDTASKLGPIEAIQKS
Host
Mouse
Reactivity
Human, Mouse
Interspecies Antigen Sequence
Mouse (88); Rat (95)
Isotype
IgG2b
Quality Control Testing
Antibody Reactive Against Recombinant Protein.
Western Blot detection against Immunogen (36.63 KDa) .
Storage Buffer
In ascites fluid
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Cell lysate)
MAP3K4 monoclonal antibody (M11A), clone X1 Western Blot analysis of MAP3K4 expression in NIH/3T3.Western Blot (Recombinant protein)
ELISA
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Gene Info — MAP3K4
Entrez GeneID
4216GeneBank Accession#
NM_005922Protein Accession#
NP_005913Gene Name
MAP3K4
Gene Alias
FLJ42439, KIAA0213, MAPKKK4, MEKK4, MTK1, PRO0412
Gene Description
mitogen-activated protein kinase kinase kinase 4
Omim ID
602425Gene Ontology
HyperlinkGene Summary
The central core of each mitogen-activated protein kinase (MAPK) pathway is a conserved cascade of 3 protein kinases: an activated MAPK kinase kinase (MAPKKK) phosphorylates and activates a specific MAPK kinase (MAPKK), which then activates a specific MAPK. While the ERK MAPKs are activated by mitogenic stimulation, the CSBP2 and JNK MAPKs are activated by environmental stresses such as osmotic shock, UV irradiation, wound stress, and inflammatory factors. This gene encodes a MAPKKK, the MEKK4 protein, also called MTK1. This protein contains a protein kinase catalytic domain at the C terminus. The N-terminal nonkinase domain may contain a regulatory domain. Expression of MEKK4 in mammalian cells activated the CSBP2 and JNK MAPK pathways, but not the ERK pathway. In vitro kinase studies indicated that recombinant MEKK4 can specifically phosphorylate and activate PRKMK6 and SERK1, MAPKKs that activate CSBP2 and JNK, respectively but cannot phosphorylate PRKMK1, an MAPKK that activates ERKs. MEKK4 is a major mediator of environmental stresses that activate the CSBP2 MAPK pathway, and a minor mediator of the JNK pathway. Two alternatively spliced transcripts encoding distinct isoforms have been described. [provided by RefSeq
Other Designations
MAP/ERK kinase kinase 4|MAPK/ERK kinase kinase 4|SSK2/SSK22 MAP kinase kinase kinase, yeast, homolog of|dJ473J16.1 (mitogen-activated protein kinase kinase kinase 4)|predicted protein of HQ0412
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Interactome
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Pathway
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Disease
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