MAP3K3 DNAxPab
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Specification
Product Description
Rabbit polyclonal antibody raised against a full-length human MAP3K3 DNA using DNAx™ Immune technology.
Technology
Immunogen
Full-length human DNA
Sequence
MNEANVMLPYSGKEEPVLPVAMTLPLPGRGPRCGTAATEGGSSFVNAVVSVLQVGVTLMLYPVSKLETVCALWALSTPALGLGLGCIEKS
Host
Rabbit
Reactivity
Human
Purification
Protein A
Quality Control Testing
Antibody reactive against mammalian transfected lysate.
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Transfected lysate)
Immunofluorescence (Transfected cell)
Flow Cytometry (Transfected cell)
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Gene Info — MAP3K3
Entrez GeneID
4215GeneBank Accession#
BC010464.1Protein Accession#
AAH10464.1Gene Name
MAP3K3
Gene Alias
MAPKKK3, MEKK3
Gene Description
mitogen-activated protein kinase kinase kinase 3
Omim ID
602539Gene Ontology
HyperlinkGene Summary
This gene product is a 626-amino acid polypeptide that is 96.5% identical to mouse Mekk3. Its catalytic domain is closely related to those of several other kinases, including mouse Mekk2, tobacco NPK, and yeast Ste11. Northern blot analysis revealed a 4.6-kb transcript that appears to be ubiquitously expressed. This protein directly regulates the stress-activated protein kinase (SAPK) and extracellular signal-regulated protein kinase (ERK) pathways by activating SEK and MEK1/2 respectively; it does not regulate the p38 pathway. In cotransfection assays, it enhanced transcription from a nuclear factor kappa-B (NFKB)-dependent reporter gene, consistent with a role in the SAPK pathway. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq
Other Designations
MAP/ERK kinase kinase 3|MAPK/ERK kinase kinase 3
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Interactome
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Disease
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