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Last updated: 2016/10/23
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MAP3K3 MaxPab mouse polyclonal antibody (B01)MaxPab

  • Catalog # : H00004215-B01
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  • Specification
  • Product Description:
  • Mouse polyclonal antibody raised against a full-length human MAP3K3 protein.
  • Immunogen:
  • MAP3K3 (AAH10464, 1 a.a. ~ 90 a.a) full-length human protein.
  • Sequence:
  • Host:
  • Mouse
  • Reactivity:
  • Human
  • Quality Control Testing:
  • Antibody reactive against mammalian transfected lysate.
  • Storage Buffer:
  • No additive
  • Storage Instruction:
  • Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
  • Note:
  • For IHC and IF applications, antibody purification with Protein A will be needed prior to use.
  • Applications
  • Western Blot (Transfected lysate)
  • Western Blot (Transfected lysate)
  • Western Blot analysis of MAP3K3 expression in transfected 293T cell line (H00004215-T01) by MAP3K3 MaxPab polyclonal antibody.

    Lane 1: MAP3K3 transfected lysate(10.01 KDa).
    Lane 2: Non-transfected lysate.
  • PDF DownloadProtocol Download
  • Application Image
  • Western Blot (Transfected lysate)
  • Western Blot (Transfected lysate)
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  • Gene Information
  • Entrez GeneID:
  • 4215
  • Gene Name:
  • MAP3K3
  • Gene Alias:
  • Gene Description:
  • mitogen-activated protein kinase kinase kinase 3
  • Gene Summary:
  • This gene product is a 626-amino acid polypeptide that is 96.5% identical to mouse Mekk3. Its catalytic domain is closely related to those of several other kinases, including mouse Mekk2, tobacco NPK, and yeast Ste11. Northern blot analysis revealed a 4.6-kb transcript that appears to be ubiquitously expressed. This protein directly regulates the stress-activated protein kinase (SAPK) and extracellular signal-regulated protein kinase (ERK) pathways by activating SEK and MEK1/2 respectively; it does not regulate the p38 pathway. In cotransfection assays, it enhanced transcription from a nuclear factor kappa-B (NFKB)-dependent reporter gene, consistent with a role in the SAPK pathway. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq
  • Other Designations:
  • MAP/ERK kinase kinase 3,MAPK/ERK kinase kinase 3
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