MAP3K1 monoclonal antibody (M01), clone 2F6
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Specification
Product Description
Mouse monoclonal antibody raised against a partial recombinant MAP3K1.
Immunogen
MAP3K1 (XP_042066, 1211 a.a. ~ 1310 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Sequence
SKNSMTLDLNSSSKCDDSFGCSSNSSNAVIPSDETVFTPVEEKCRLDVNTELNSSIEDLLEASMPSSDTTVTFKSEVAVLSPEKAENDDTYKDDVNHNQK
Host
Mouse
Reactivity
Human
Isotype
IgG2a kappa
Quality Control Testing
Antibody Reactive Against Recombinant Protein.
Western Blot detection against Immunogen (36.63 KDa) .
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Recombinant protein)
Sandwich ELISA (Recombinant protein)
Detection limit for recombinant GST tagged MAP3K1 is approximately 0.03ng/ml as a capture antibody.ELISA
In situ Proximity Ligation Assay (Cell)
Proximity Ligation Analysis of protein-protein interactions between MAPK3 and MAP3K1. HeLa cells were stained with anti-MAPK3 rabbit purified polyclonal 1:1200 and anti-MAP3K1 mouse monoclonal antibody 1:50. Each red dot represents the detection of protein-protein interaction complex, and nuclei were counterstained with DAPI (blue). -
Gene Info — MAP3K1
Entrez GeneID
4214GeneBank Accession#
XM_042066Protein Accession#
XP_042066Gene Name
MAP3K1
Gene Alias
MAPKKK1, MEKK, MEKK1
Gene Description
mitogen-activated protein kinase kinase kinase 1
Omim ID
600982Gene Ontology
HyperlinkGene Summary
MAP3K, or MEK kinase, is a serine/threonine kinase that occupies a pivotal role in a network of phosphorylating enzymes integrating cellular responses to a number of mitogenic and metabolic stimuli, including insulin (MIM 176730) and many growth factors.[supplied by OMIM
Other Designations
MAP/ERK kinase kinase 1|MAPK/ERK kinase kinase 1|MEK kinase 1|OTTHUMP00000065818
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Interactome
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Disease
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