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Last updated: 2017/3/19

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MDM4 rabbit monoclonal antibody

  • Catalog # : H00004194-K
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  • Specification
  • Product Description:
  • Rabbit monoclonal antibody raised against a human MDM4 peptide using ARM Technology.
  • Immunogen:
  • A synthetic peptide of human MDM4 is used for rabbit immunization.
    Customer or Abnova will decide on the preferred peptide sequence.
  • Host:
  • Rabbit
  • Reactivity:
  • Human
  • Purification:
  • Protein A
  • Isotype:
  • IgG
  • Quality Control Testing:
  • Antibody reactive against human MDM4 peptide by ELISA and mammalian transfected lysate by Western Blot.
  • Storage Buffer:
  • In 1x PBS, pH 7.4
  • Storage Instruction:
  • Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
  • Note:
  • 1. Customer may provide cell or tissue lysate for antibody screening.
    2. Rabbit monoclonal antibody generated by ARM technology is amenable to antibody engineering including F(ab)2, IgG, scFv and different Fc and non-Fc conjugates per customer request.
  • Library Construction:
  • Non-fusion antibody library from rabbit spleen (ARM Technology).
  • Expression:
  • Overexpression vector and transfection into 293H cell line.
  • Deliverable:
  • Up to three rabbit IgG clones of 1 mg each will be delivered to customer.
  • Applications
  • ELISA
  • Application Image
  • Western Blot (Transfected lysate)
  • ELISA
  • Gene Information
  • Entrez GeneID:
  • 4194
  • GeneBank Accession#:
  • MDM4
  • Gene Name:
  • MDM4
  • Gene Alias:
  • DKFZp781B1423,HDMX,MDMX,MGC132766,MRP1
  • Gene Description:
  • Mdm4 p53 binding protein homolog (mouse)
  • Gene Summary:
  • The human MDM4 gene, which plays a role in apoptosis, encodes a 490-amino acid protein containing a RING finger domain and a putative nuclear localization signal. The MDM4 putative nuclear localization signal, which all Mdm proteins contain, is located in the C-terminal region of the protein. The mRNA is expressed at a high level in thymus and at lower levels in all other tissues tested. MDM4 protein produced by in vitro translation interacts with p53 via a binding domain located in the N-terminal region of the MDM4 protein. MDM4 shows significant structural similarity to p53-binding protein MDM2. Two transcript variants, one protein-coding and the other likely not to be protein-coding, have been found for this gene. [provided by RefSeq
  • Other Designations:
  • MDM4-related protein 1,Mdm4, transformed 3T3 cell double minute 4, p53 binding protein,double minute 4, human homolog of; p53-binding protein,mouse double minute 4 homolog,p53-binding protein
  • Gene Pathway
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