Western blot analysis of MCC over-expressed 293 cell line, cotransfected with MCC Validated Chimera RNAi ( Cat # H00004163-R01V ) (Lane 2) or non-transfected control (Lane 1). Blot probed with MCC monoclonal antibody (M01), clone 1A7 (Cat # H00004163-M01 ). GAPDH ( 36.1 kDa ) used as specificity and loading control.
This gene is a candidate colorectal tumor suppressor gene that is thought to negatively regulate cell cycle progression. The orthologous gene in the mouse expresses a phosphoprotein associated with the plasma membrane and membrane organelles, and overexpression of the mouse protein inhibits entry into S phase. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq