MC1R DNAxPab
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Specification
Product Description
Rabbit polyclonal antibody raised against a partial-length human MC1R DNA using DNAx™ Immune technology.
Technology
Immunogen
Extracellular membrane domain (ECD) human DNA
Host
Rabbit
Reactivity
Human
Purification
Protein A
Quality Control Testing
Antibody reactive against mammalian transfected lysate.
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Transfected lysate)
Immunofluorescence (Transfected cell)
Flow Cytometry (Transfected cell)
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Gene Info — MC1R
Entrez GeneID
4157GeneBank Accession#
NM_002386.2Protein Accession#
NP_002377.3Gene Name
MC1R
Gene Alias
MGC14337, MSH-R, SHEP2
Gene Description
melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor)
Gene Ontology
HyperlinkGene Summary
This intronless gene encodes the receptor protein for melanocyte-stimulating hormone (MSH). The encoded protein, a seven pass transmembrane G protein coupled receptor, controls melanogenesis. Two types of melanin exist: red pheomelanin and black eumelanin. Gene mutations that lead to a loss in function are associated with increased pheomelanin production, which leads to lighter skin and hair color. Eumelanin is photoprotective but pheomelanin may contribute to UV-induced skin damage by generating free radicals upon UV radiation. Binding of MSH to its receptor activates the receptor and stimulates eumelanin synthesis. This receptor is a major determining factor in sun sensitivity and is a genetic risk factor for melanoma and non-melanoma skin cancer. Over 30 variant alleles have been identified which correlate with skin and hair color, providing evidence that this gene is an important component in determining normal human pigment variation. [provided by RefSeq
Other Designations
melanocortin 1 receptor|melanocyte stimulating hormone receptor|melanotropin receptor
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Interactome
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Pathway
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Disease
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