MAN2B1 293T Cell Transient Overexpression Lysate(Denatured)
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More Files
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SDS-PAGE Gel
MAN2B1 transfected lysate.
Western Blot
Lane 1: MAN2B1 transfected lysate ( 111.32 KDa)
Lane 2: Non-transfected lysate.
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Specification
Transfected Cell Line
293T
Plasmid
pCMV-MAN2B1 full-length
Host
Human
Theoretical MW (kDa)
111.32
Quality Control Testing
Transient overexpression cell lysate was tested with Anti-MAN2B1 antibody (H00004125-B01) by Western Blots.
SDS-PAGE Gel
MAN2B1 transfected lysate.
Western Blot
Lane 1: MAN2B1 transfected lysate ( 111.32 KDa)
Lane 2: Non-transfected lysate.Storage Buffer
1X Sample Buffer (50 mM Tris-HCl, 2% SDS, 10% glycerol, 300 mM 2-mercaptoethanol, 0.01% Bromophenol blue)
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot
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Gene Info — MAN2B1
Entrez GeneID
4125GeneBank Accession#
NM_000528.2Protein Accession#
NP_000519.2Gene Name
MAN2B1
Gene Alias
LAMAN, MANB
Gene Description
mannosidase, alpha, class 2B, member 1
Gene Ontology
HyperlinkGene Summary
This gene encodes an enzyme that hydrolyzes terminal, non-reducing alpha-D-mannose residues in alpha-D-mannosides. Its activity is necessary for the catabolism of N-linked carbohydrates released during glycoprotein turnover and it is member of family 38 of glycosyl hydrolases. The full length protein is processed in two steps. First, a 49 aa leader sequence is cleaved off and the remainder of the protein is processed into 3 peptides of 70 kDa, 42 kDa (D) and 13/15 kDa (E). Next, the 70 kDa peptide is further processed into three peptides (A, B and C). The A, B and C peptides are disulfide-linked. Defects in this gene have been associated with lysosomal alpha-mannosidosis. [provided by RefSeq
Other Designations
lysosomal acid alpha-mannosidase|mannosidase, alpha B, lysosomal
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