SMAD7 monoclonal antibody (M09), clone 1G10
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More Files
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Specification
Product Description
Mouse monoclonal antibody raised against a partial recombinant SMAD7.
Immunogen
SMAD7 (NP_005895, 160 a.a. ~ 260 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Sequence
CKVFRWPDLRHSSEVKRLCCCESYGKINPELVCCNPHHLSRLCELESPPPPYSRYPMDFLKPTADCPDAVPSSAETGGTNYLAPGGLSDSQLLLEPGDRSH
Host
Mouse
Reactivity
Human
Interspecies Antigen Sequence
Mouse (99); Rat (99)
Isotype
IgG2a Kappa
Quality Control Testing
Antibody Reactive Against Recombinant Protein.
Western Blot detection against Immunogen (36.85 KDa) .
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Recombinant protein)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunoperoxidase of monoclonal antibody to SMAD7 on formalin-fixed paraffin-embedded human placenta. [antibody concentration 3 ug/ml]Sandwich ELISA (Recombinant protein)
Detection limit for recombinant GST tagged SMAD7 is 0.3 ng/ml as a capture antibody.ELISA
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Gene Info — SMAD7
Entrez GeneID
4092GeneBank Accession#
NM_005904Protein Accession#
NP_005895Gene Name
SMAD7
Gene Alias
CRCS3, FLJ16482, MADH7, MADH8
Gene Description
SMAD family member 7
Gene Ontology
HyperlinkGene Summary
Drosophila) homolog 7|MAD
Other Designations
MAD (mothers against decapentaplegic, Drosophila) homolog 7|MAD, mothers against decapentaplegic homolog 7|Mothers against decapentaplegic, drosophila, homolog of, 7|SMAD, mothers against DPP homolog 7
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Interactome
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Pathway
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Disease
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Publication Reference
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SMAD7 is a novel independent predictor of survival in patients with cutaneous melanoma.
Kaczorowski M, Biecek P, Donizy P, Pieniazek M, Matkowski R, Halon A.
Translational Research 2019 Feb; 204:72.
Application:IHC-P, Human, Human cutaneous melanoma.
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Association of the infiltration of tumor-associated macrophages, expression of Smad7 protein and prognosis in oral squamous cell carcinoma.
Wei W, Hu-Jie C.
Archives of Oral Biology 2018 Nov; 95:22.
Application:IHC-P, Human, Human oral squamous cell carcinoma.
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Transforming growth factor-β1 SMAD effectors and medial cell number in ascending aorta diseases.
Aparecida-Silva R, Borges LF, Kessler K, Dias RR, Moreira LFP, Kalil J, Gutierrez PS.
Cardiovascular pathology 2016 May; 25(3):240.
Application:IHC-P, Human, Aortic.
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Aberrant expression in multiple components of the transforming growth factor-?]1-induced Smad signaling pathway during 7,12-dimethylbenz[a]anthracene-induced Hamster buccal-pouch squamous-cell carcinogenesis.
Chen YK, Yang SH, Huang AH, Hsue SS, Lin LM.
Oral Oncology 2011 Apr; 47(4):262.
Application:IHC-P, Mouse, Mouse tumors.
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SMAD7 is a novel independent predictor of survival in patients with cutaneous melanoma.
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